1,4-Cyclohexanedione

Elevate your pharmaceutical intermediate and heterocyclic synthesis with 1,4-cyclohexanedione (CAS No.: 637-88-7, CAT No.: SRCC-019). This symmetrical cyclohexane-1,4-dione serves as a core building block for ramatroban, triptans, analgesics, and liquid crystal materials, offering dual carbonyl reactivity for regioselective mono-protection and diverse annulation strategies.

With a molecular formula of C₆H₈O₂ and a molecular weight of 112.13 g/mol, 1,4-cyclohexanedione appears as a white to slightly yellow crystalline solid with a melting point of 77-78.5°C. It exhibits good solubility in water and polar organic solvents, supporting clean reactions and facile purification in multi-step sequences toward APIs and advanced materials.

Product Highlights

Technical Features & Benefits

• • Symmetrical 1,4-Dicarbonyl: Enables regioselective mono-ketalization to 1,4-dioxaspiro[4.5]decan-8-one, a privileged intermediate for ramatroban and triptan synthesis.

• • Versatile Annulation Partner: Undergoes Robinson annulation, Pauson?Khand, and other cycloadditions to access fused carbocycles and heterocycles.

• • High Crystalline Purity: Well-defined melting point and analytical profile support robust QC and scale-up from lab to production.

• • Water-Soluble Reactivity: Polar solubility facilitates aqueous workups, enzyme-mediated reactions, and green chemistry protocols.

• • Proven Pharmaceutical Utility: Documented in routes to thromboxane antagonists, analgesics, and conducting materials.

Application Areas

• • Key starting material for ramatroban (thromboxane A2 antagonist) via monoethylene ketal intermediate.

• • Precursor to triptans (frovatriptan), epibatidine analogs, and other CNS-active heterocycles.

• • Building block for liquid crystals, organic insecticides, and plant growth regulators.

• • Synthetic reagent in oscillator chemistry studies and bromoorganic synthesis.

• • Intermediate for advanced materials including conducting polymers and quinone derivatives.

Safety & Handling

• • Wear appropriate PPE: gloves, safety goggles, and lab coat to prevent skin and eye contact.

• • Handle in a well-ventilated area; combustible solid?incompatible with strong oxidizing agents.

• • Store tightly closed in a cool, dry, well-ventilated place away from moisture, light, and incompatibles.

• • Dispose of waste according to local, regional, and national hazardous waste regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Expertise in cyclohexanedione derivatives, pharmaceutical intermediates, and ketal-protected synthons with rigorous quality assurance.

• • Custom synthesis capabilities for mono-ketals, annulated products, and scale-up from milligrams to kilograms.

• • Full analytical documentation: COA, NMR, HPLC, LC-MS tailored to regulatory and process requirements.
• Technical collaboration for route optimization, impurity control, and ramatroban/triptan intermediate supply.

Request a Quote or Sample Today! Propel your API synthesis, heterocyclic construction, and materials innovation with SRIRAMCHEM?s premium 1,4-cyclohexanedione. Contact the expert team for pricing, availability, or custom synthesis discussions.