Methyl 2-(4-bromophenyl)-2-methylpropionate

Advance your fexofenadine and bilastine API synthesis with Methyl 2-(4-bromophenyl)-2-methylpropionate (CAS No.: 154825-97-5, CAT No.: SRCM-027). This brominated aryl isobutyrate ester serves as a key intermediate in non-sedating antihistamine manufacturing, enabling selective para-bromination followed by cross-coupling and hydrolysis sequences.

With a molecular formula of C₁₁H₁₃BrO₂ and a molecular weight of 257.12 g/mol, it appears as a clear colorless to pale yellow liquid with good stability under ambient conditions. Soluble in common organic solvents and compatible with Pd-catalyzed processes, its ester functionality supports clean hydrolysis to the corresponding carboxylic acid in fexofenadine routes.

Product Highlights

Technical Features & Benefits

• • Fexofenadine/Bilastine Intermediate: Direct precursor to 2-(4-bromophenyl)-2-methylpropanoic acid via base hydrolysis, key in antihistamine API synthesis.

• • Para-Bromo Selectivity: Clean 4-bromophenyl substitution enables Pd-catalyzed cross-coupling with piperidine/boronic acid fragments.

• • Liquid Handling Advantage: Low-viscosity liquid facilitates accurate dosing, reaction setup, and purification in continuous flow or batch processes.

• • High Chemical Stability: Ester group withstands bromination and coupling conditions, supporting robust multi-step sequences.

• • Process-Optimized Purity: ?98% GC purity suitable for GMP-scale antihistamine intermediate campaigns.

Application Areas

• • Key ester intermediate in fexofenadine hydrochloride manufacturing routes.

• • Precursor to bilastine and related second-generation antihistamine APIs.

• • Building block for cross-coupling diversification in medicinal chemistry SAR studies.

• • Reference standard for process impurity profiling and analytical method validation.

• • Synthetic intermediate for quaternary ?-aryl ester libraries and chiral auxiliary preparation.

Safety & Handling

• • May cause skin/eye irritation; wear gloves, safety goggles, and lab coat during handling.

• • Handle in well-ventilated area; avoid inhalation of vapors and prolonged skin contact.

• • Store under nitrogen in tightly closed containers away from strong bases, oxidizers, and light.
• Dispose of as hazardous chemical waste per local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Specialized expertise in fexofenadine intermediates, antihistamine building blocks, and cross-coupling reagents.

• • Custom synthesis and scale-up from research to multi-kilogram API intermediate supply.

• • Complete analytical support: COA, NMR, GC/HPLC, LC-MS for regulatory compliance.
• Technical partnership for route optimization, impurity control, and technology transfer.

Request a Quote or Sample Today! Streamline your fexofenadine and bilastine production with SRIRAMCHEM?s premium Methyl 2-(4-bromophenyl)-2-methylpropionate. Contact the expert team for pricing, availability, or custom synthesis requirements.