2,6-Diamino-4-chloropyrimidine 1-oxide

Optimize your minoxidil impurity profiling and antihypertensive research with 2,6-diamino-4-chloropyrimidine 1-oxide (CAS No.: 35139-67-4, CAT No.: SRCD-035). Designated as Minoxidil Impurity A (EP/USP), this N-oxide serves as a critical reference standard for analytical method validation and process control in the synthesis of the antihypertensive and hair growth agent minoxidil.

With a molecular formula of C₄H₅ClN₄O and a molecular weight of 160.56 g/mol, it appears as a white to off-white or creamish solid with decomposition around 185°C. Slightly soluble in DMSO, dichloromethane, and methanol, its light-sensitive nature requires inert atmosphere storage, making it ideal for stability-indicating HPLC methods and regulatory submissions.

Product Highlights

Technical Features & Benefits

• • Minoxidil EP/USP Impurity A: Official reference standard for regulatory compliance and stability-indicating method validation in minoxidil formulations.

• • Light-Sensitive N-Oxide: Characteristic UV absorbance and chromatographic behavior enable precise impurity quantification at trace levels.

• • Synthesis Intermediate: Precursor in oxidative routes to minoxidil via piperonyl substitution of the 4-chloro position.

• • High Analytical Purity: ?98% HPLC purity with full characterization supports forced degradation studies and shelf-life determinations.

• • Stable Solid Form: Well-defined decomposition profile (185?C) and inert storage conditions ensure reliability for long-term reference use.

Application Areas

• • Certified reference material for minoxidil impurity profiling per EP/USP monographs.

• • System suitability standard and calibrant in HPLC/LC-MS methods for antihypertensive quality control.

• • Synthetic intermediate in minoxidil process development and analogue synthesis.

• • Tool compound for stress testing, photostability studies, and oxidative degradation pathway research.

• • Research standard for pyrimidine N-oxide chemistry and nucleophilic aromatic substitution studies.

Safety & Handling

• • Wear appropriate PPE: gloves, safety goggles, lab coat; handle as a potential irritant.

• • Light-sensitive?protect from exposure during handling and storage.

• • Store under nitrogen/inert atmosphere at 2?8?C in tightly closed amber containers.
• Dispose of as hazardous chemical waste per local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Specialized expertise in minoxidil impurities, antihypertensive intermediates, and certified reference standards.

• • Custom synthesis of related N-oxides and process impurities from microgram to multi-gram scale.

• • Comprehensive analytical documentation: COA, NMR, HPLC, LC-MS fully compliant with EP/USP requirements.

• Technical support for method transfer, impurity qualification, and regulatory dossier preparation.

Request a Quote or Sample Today! Ensure minoxidil quality compliance and accelerate your antihypertensive development with SRIRAMCHEM?s premium 2,6-diamino-4-chloropyrimidine 1-oxide. Contact the expert team for pricing, availability, or custom reference standard requirements.