7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine

Accelerate your antimalarial API development with 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS No.: 6626-40-0, CAT No.: SRCD-034). This dihalogenated naphthyridine serves as a critical intermediate in the synthesis of pyronaridine tetraphosphate, enabling selective nucleophilic aromatic substitution at the activated 10-chloro position followed by Mannich-type elaboration.

With a molecular formula of C₁₃H₈Cl₂N₂O and a molecular weight of 279.12 g/mol, it appears as a pale yellow solid with a melting point of 186-187°C. Sparingly soluble in chloroform, DMSO (heated), and methanol (heated), its electron-deficient heteroaromatic core supports clean SNAr reactivity under acidic or thermal conditions typical of pyronaridine process routes.

Product Highlights

Technical Features & Benefits

• • Pyronaridine Key Intermediate: Selective displacement of the 10-chloro position with 4-aminophenol under acidic conditions provides the pivotal biaryl linkage in pyronaridine synthesis.

• • Dual Halogen Activation: Electron-deficient naphthyridine core enables stepwise SNAr reactivity, with 7-chloro retained for downstream functionalization.

• • High Thermal Stability: Well-defined melting point (186?187?C) and crystalline form support robust purification and scale-up.

• • Process-Optimized Material: ?98% purity suitable for GMP campaigns, impurity profiling, and technology transfer to commercial production.

• • Inert Atmosphere Stability: Recommended cold storage (2?8?C) ensures long-term stability for multi-kilogram campaigns.

Application Areas

• • Critical intermediate in pyronaridine tetraphosphate manufacturing routes for antimalarial combination therapies.

• • Building block for naphthyridine-based kinase inhibitors and antimicrobial agents.

• • Platform for nucleophilic aromatic substitution studies and late-stage diversification.

• • Reference standard for pyronaridine process validation and impurity control.

• • Research tool in heterocyclic methodology development and medicinal chemistry SAR around aza-acridine scaffolds.

Safety & Handling

• • Wear appropriate PPE: gloves, safety goggles, lab coat; avoid dust inhalation and skin/eye contact.

• • Handle in a well-ventilated fume hood; potential skin and respiratory irritant.

• • Store under inert gas (N₂ or Ar) at 2?8?C, protected from moisture and light in tightly closed containers.

• • Dispose of as hazardous chemical waste per local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Proven track record in antimalarial intermediates and naphthyridine synthesis with GMP-compliant quality systems.

• • Custom scale-up from research quantities to multi-kilogram API intermediate supply.

• • Complete analytical package: COA, NMR, HPLC, LC-MS supporting regulatory filings and process validation.
• Expert technical collaboration for pyronaridine route optimization, impurity control, and supply chain reliability.

Request a Quote or Sample Today! Fast-track your pyronaridine production and antimalarial development with SRIRAMCHEM?s premium 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine. Contact the expert team for pricing, availability, or custom synthesis support.