4-Amino-2,6-bis(pyrrolidin-1-ylmethyl)phenol trihydrochloride

Advance your API impurity profiling and antimalarial research with 4-amino-2,6-bis(pyrrolidin-1-ylmethyl)phenol trihydrochloride (CAS No.: 749260-32-0, CAT No.: SRCA-032). This polyamine phenolic salt is a known pyronaridine-related impurity and key intermediate, making it valuable for method development, reference standard applications, and structure?activity exploration in heteroaromatic antimalarial scaffolds.

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With a molecular formula of C₁₆H₂₈Cl₃N₃O and a molecular weight of 384.77 g/mol, it is typically obtained as a hygroscopic solid, forming a stable trihydrochloride for convenient handling and storage in analytical and synthetic laboratories. As a salt of the free base 4-amino-2,6-bis(pyrrolidin-1-ylmethyl)phenol, it offers improved aqueous compatibility while retaining the basic tertiary amine functions needed for diverse derivatization and conjugation strategies.

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Product Highlights

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Technical Features & Benefits

• Pyronaridine Impurity Standard: Well-characterized impurity of pyronaridine, useful as a reference for impurity profiling and stability-indicating method validation in antimalarial drug products.

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• Polyamine Phenol Scaffold: Combines a phenolic core with two pyrrolidinylmethyl substituents and an amino group, enabling diverse salt formation and derivatization in medicinal chemistry programs.

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• Analytical Grade Quality: High-purity material optimized for LC?MS, HPLC, and NMR characterization in regulatory and research environments.
• Stable Trihydrochloride Salt: Enhanced stability and handling compared with the free base, supporting reproducible sample preparation and storage.

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• Versatile Solubility Profile: Good solubility in water and polar protic solvents facilitates use in bioanalytical, formulation, and in vitro assay workflows.

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Application Areas

• Reference standard and process impurity for pyronaridine and related antimalarial APIs.

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• System suitability and calibration standard in HPLC/LC?MS methods for impurity profiling.
• Intermediate and building block for structure?activity relationship (SAR) studies on aminoalkyl phenolic antimalarial derivatives.

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• Tool compound for investigating physicochemical properties and ionization behavior of polyamine phenol salts.
• Research in API synthesis optimization, stress studies, and forced degradation pathway elucidation.

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Safety & Handling

• Wear appropriate PPE: gloves, safety goggles, and lab coat when handling this compound.
• Handle in a well-ventilated area; avoid inhalation, ingestion, and contact with skin or eyes.
• Store in a tightly closed container in a cool, dry, well-ventilated environment away from moisture and incompatible materials.
• Dispose of waste and contaminated materials in accordance with local, regional, and national regulations.

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Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing and sourcing of pharmaceutical impurities and reference standards with stringent quality control for high purity and batch-to-batch consistency.

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• Custom synthesis and scale-up capabilities from milligram reference quantities to multi-gram development lots.
• Comprehensive analytical documentation support, including COA and available NMR, HPLC, LC?MS, and other characterization data on request.
• Responsive technical support and project-driven collaboration to align impurity and intermediate supply with your development timelines.

Request a Quote or Sample Today! Accelerate your antimalarial API development, impurity profiling, and analytical method validation with SRIRAMCHEM?s premium 4-amino-2,6-bis(pyrrolidin-1-ylmethyl)phenol trihydrochloride. Contact the expert team for pricing, availability, or to discuss custom synthesis and documentation requirements.