2-(4-Bromophenyl)-2-methylpropionic acid

Strengthen your antihistamine and chiral intermediate pipelines with 2-(4-bromophenyl)-2-methylpropionic acid (CAS No.: 32454-35-6, CAT No.: SRCB-081). This brominated aryl isobutyric acid is a key industrial intermediate in the synthesis of fexofenadine and related pharmaceutical candidates, and serves as a robust building block for aryl-alkyl carboxylic acid derivatives in medicinal and process chemistry.

With a molecular formula of C₁₀H₁₁BrO₂ and a molecular weight of 243.10 g/mol, 2-(4-bromophenyl)-2-methylpropionic acid typically appears as a white to off-white or cream crystalline powder with a melting point of about 122-124°C and high thermal stability under standard handling conditions. It is sparingly soluble in water but dissolves well in organic solvents such as methanol, ethanol, dichloromethane, and ethyl acetate, making it suitable for multi-step synthetic sequences and chiral resolution strategies.

Product Highlights

Technical Features & Benefits

• • Key Fexofenadine Intermediate: Widely documented as a crucial intermediate in industrial routes to fexofenadine, ensuring direct relevance for antihistamine API synthesis and process optimization.

• • Brominated Aryl Isobutyric Acid: Combines a reactive para-bromophenyl ring with a tertiary ?-carbon, offering a robust platform for nucleophilic substitution, metal-catalyzed coupling, and side-chain elaboration.

• • High Chemical Stability: Solid, crystalline material with a well-defined melting range and good shelf stability under recommended storage conditions, ideal for scale-up and long-term projects.

• • Versatile in Organic Synthesis: Carboxylic acid functionality enables straightforward esterification, amidation, and salt formation to access diverse analogues.

• • Optimized for R&D and Manufacturing: Offered at high purity suitable for route scouting, impurity profiling, and technology-transfer into commercial production.

Application Areas

• • Intermediate in the synthesis of the non-sedating antihistamine fexofenadine and related arylalkylcarboxylic APIs.

• • Building block for chiral and achiral carboxylic acid derivatives in medicinal chemistry and lead optimization.

• • Precursor for esters, amides, and salts used in pharmacological screening and formulation development.

• • Research tool for studying structure?activity relationships in bromophenyl-containing drug candidates.

• • Fine chemical intermediate for specialty materials and advanced organic synthesis.

Safety & Handling

• • May be harmful if swallowed, inhaled, or in contact with skin; wear appropriate PPE including gloves, safety goggles, and lab coat.

• • Handle in a well-ventilated area or chemical fume hood to minimize dust exposure; avoid breathing dust or aerosols.

• • Store in tightly closed containers at room temperature, away from heat, sparks, open flame, and strong oxidizing agents.

• • Dispose of material and contaminated packaging as hazardous waste in accordance with local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Proven expertise in pharmaceutical intermediates and antihistamine-related building blocks with rigorous quality control and documentation.

• • Custom synthesis and scale-up capabilities for 2-(4-bromophenyl)-2-methylpropionic acid and downstream derivatives from gram to multi-kilogram scale.

• • Comprehensive analytical package including COA and available NMR, HPLC/GC, and LC?MS data aligned with regulatory expectations.
• Agile technical and customer support to help integrate this intermediate into your fexofenadine or related API manufacturing routes.

Request a Quote or Sample Today! Power your antihistamine API development, scale-up, and impurity control programs with SRIRAMCHEM?s premium 2-(4-bromophenyl)-2-methylpropionic acid. Contact the expert team for pricing, availability, or to discuss custom synthesis and analytical support.