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Thiomersal, Thimerosal,54-64-8, Merthiolate

Research ChemicalsThiomersal

SKU: SRCT-003

₹10,000.00 – ₹198,000.00

Name: Thiomersal, Thimerosal, Merthiolate

CAT No.: SRCT-003

CAS No.: 54-64-8

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Description
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Additional information

Description

Thiomersal

IUPAC name Ethyl(2-mercaptobenzoato-(2-)-O,S) mercurate(1-) sodium
Other names Mercury((o-carboxyphenyl)thio)ethyl sodium salt, sodium ethylmercurithiosalicylate, Merthiolate
CAS Number	54-64-8
Beilstein Reference	8169555
ChEBI	CHEBI:9546
ChEMBL	ChEMBL508338
ChemSpider	10772045
DrugBank	DB11590
ECHA InfoCard	100.000.192
EC Number	200-210-4
Gmelin Reference	1677155
PubChem SID	461483237
RTECS number	OV8400000
UNII	2225PI3MOV
CompTox Dashboard (EPA)	DTXSID3025540
Properties
Chemical formula	C₉H₉HgNaO₂S
Molar mass	404.81 g/mol
Appearance	White or slightly yellow powder
Density	2.508 g/cm
Melting point	232 to 233 °C (450 to 451 °F; 505 to 506 K) (decomposition)
Solubility in water	1000 g/L (20 °C)
Pharmacology
ATC code	D08AK06 (WHO)
Hazards
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H300, H310, H330, H373, H410
Precautionary statements	P260, P273, P280, P301, P302, P304, P310, P330, P340, P352
NFPA 704	3 1 1
Flash point	250 °C (482 °F; 523 K)

It also known as thimerosal, is a chemical compound,that has gained significant attention due to its widespread use as a preservative in vaccines and other medical and personal care products. This organic compound contains mercury and sulfur, and its unique properties make it an effective antimicrobial agent, extending the shelf life of various products.

Chemical Structure and Properties: it is a thiol (sulfhydryl) compound comprising ethylmercury and thiosalicylate. Its chemical formula is C9H9HgNaO2S and its systematic name is sodium ethylmercuric thiosalicylate. It is a white crystalline powder that is soluble in water and alcohol. it releases low levels of ethylmercury, a derivative of mercury, which acts as a preservative by inhibiting the growth of bacteria and fungi that can degrade or spoil products.

Uses of thiomersal:

1. Vaccine Preservative: One of the most well-known uses of it is as a preservative in vaccines. It is added to some vaccines to prevent contamination and growth of microorganisms during the manufacturing and storage processes. This helps maintain the vaccine’s potency and effectiveness over time, ensuring that the vaccine remains safe for use.

2. Topical Antiseptic: it is used in topical antiseptic formulations, such as skin creams and ointments. It helps prevent the growth of bacteria, making these products more effective in treating minor cuts, wounds, and skin infections.

3. Contact Lens Solutions: Some contact lens solutions contain it to disinfect and clean lenses, preventing the growth of microorganisms that can cause eye infections.

4. Cosmetic and Personal Care Products: In the past, it was used in cosmetics and personal care products like mascara and eye makeup to prevent bacterial growth. However, its use in these products has been largely phased out due to concerns about potential mercury exposure.

Controversies and Concerns: It has been a subject of controversy and debate, primarily due to concerns about mercury exposure and its potential health effects. Mercury is a known toxic substance that can have harmful effects on the nervous system, especially in developing fetuses and young children. The controversy surrounding it largely revolves around its use in vaccines and its alleged association with developmental disorders like autism.

However, extensive research has been conducted to assess the safety of it in vaccines, and the overwhelming scientific consensus is that it in vaccines does not cause autism or other developmental disorders.

Regulatory agencies such as the World Health Organization (WHO), the U.S. Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC) have reviewed the available evidence and concluded that it is in vaccines is safe and effective