H-Leu-OtBu.HCl

Streamline your peptide synthesis, pharmaceutical research, and amino acid modification workflows with H-Leu-OtBu.HCl (CAS No.: 2748-02-9, CAT No.: SRCL-007). Also known as L-leucine tert-butyl ester hydrochloride, this compound is a protected amino acid derivative commonly used as a building block in both solid- and solution-phase peptide synthesis. The tert-butyl (OtBu) ester protects the C-terminal carboxyl group, enabling selective N-terminal modifications while preventing undesired condensation, and the hydrochloride salt form guarantees enhanced stability and solubility. H-Leu-OtBu.HCl is widely employed in the synthesis of protected peptides, preparation of peptidomimetics, and drug candidate development.

Molecular formula: C₁₀H₂₁NO₂·HCl, Molecular weight: 223.74 g/mol. This product is supplied as a white to almost white powder or crystalline solid, with a melting point around 167 °C. Specific rotation [α]₂₀/D: +18° to +21° (c=2, EtOH). It is highly soluble in polar solvents (water, DMSO, methanol), purity ≥98%. Store at room temperature in a cool, dry, and dark place (<15°C recommended), protected from moisture and preferably under inert atmosphere for long-term stability.

Product Highlights

Technical Features & Benefits

• Preferred Peptide Synthon: OtBu protection aids in regioselective peptide bond formation and prevents C-terminal racemization.
• High Solubility & Stability: Ready for use in aqueous and organic media, ensures better yields in SPPS/LPPS.
• Batch-to-Batch Consistency: Analytical and synthetic purity verified (≥98%) for reliable results.
• N-terminal Reactivity: Free amino group for selective coupling and bioconjugation schemes.
• Long-Term Storage: Stable under inert and dry conditions for extended shelf life.

Application Areas

• Peptide and peptidomimetic synthesis (SPPS, LPPS)
• Amino acid modification and protecting group strategies
• Building block for drug discovery and pharmaceutical chemistry
• Stereoselective and structure-activity studies

Safety & Handling

• Precautions: Use PPE including gloves, goggles, and lab coat. Avoid inhalation, ingestion, and contact with eyes or skin.
• Storage: Store sealed in dry, cool, dark environment (<15°C), protected from moisture (hygroscopic).
• Disposal: Dispose as per local, state, and national chemical safety protocols.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Batch Integrity: Manufactured to the highest purity standards since 2013, with reliable batch QA and analytical data.
• Custom Supply: Orders fulfilled from grams to kilogram scale, with customizable delivery solutions for your R&D or production.
• Technical and Analytical Documentation: Includes Certificate of Analysis (COA) and advanced purity data.
• Expert Support: Responsive technical and customer assistance throughout your peptide synthesis journey.

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Advance your peptide science with SRIRAMCHEM’s H-Leu-OtBu.HCl. Contact us for competitive pricing, custom orders, or technical information.