H-Ser(tbu)-Otbu.HCl

Advance your peptide synthesis with H-Ser(tbu)-Otbu.HCl (CAS No.: 51537-21-4, CAT No.: SRCS-004). Also known as O-tert-butyl-L-serine tert-butyl ester hydrochloride, this fully protected serine derivative features tert-butyl (tBu) protection on both the side chain hydroxy and carboxyl groups, in hydrochloride form. It is widely employed as a building block in solid-phase peptide synthesis (SPPS), enabling orthogonal deprotection and streamlined assembly of complex peptides.

The molecular formula is C₁₁H₂₄ClNO₃, with a molecular weight of 253.77 g/mol. H-Ser(tbu)-Otbu.HCl is supplied as a white crystalline solid or powder, with a melting point of 170–177 °C. It is soluble in water and common organic solvents, delivering high stability and effective protection during multiple synthetic steps.

Product Highlights

Technical Features & Benefits

• Dual tBu Protection: Shields both the carboxyl and hydroxy groups for robust, orthogonal protection in SPPS.
• High Purity and Stability: ≥98% purity for reliability; stable at room temperature and during extended storage under inert conditions.
• Optimized for Peptide Chemistry: Facilitates the synthesis of serine-containing peptides and minimizes side reactions associated with unprotected groups.
• Excellent Solubility: Soluble in aqueous and organic media for flexible handling in multiple synthetic steps.
• Analytical Documentation: COA, HPLC, and spectral data supplied with each batch for identity and quality confirmation.

Application Areas

• Solid-phase peptide synthesis (SPPS) and combinatorial chemistry
• Synthesis of protected serine-containing peptides
• Medicinal and pharmaceutical research
• Development of peptidomimetics, peptide libraries, and custom sequences
• Building block for synthesis of modified and functionalized peptides

Safety & Handling

• Wear gloves, lab coat, and safety goggles when handling
• Avoid contact with skin or eyes; do not ingest or inhale
• Store tightly sealed under inert atmosphere at 2–8 °C, protected from light and moisture
• Dispose of waste according to local regulatory requirements

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Trusted supplier of high-quality, protected amino acid derivatives since 2013
• Batch-specific analytical verification and full documentation
• Scalable custom synthesis and responsive technical support
• Fast delivery and reliable customer service

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Optimize your peptide synthesis workflow with SRIRAMCHEM’s premium H-Ser(tbu)-Otbu.HCl. Contact us for pricing, samples, or custom synthesis solutions.