3-Amino-5-bromobenzoic acid

Advance your aromatic building-block and API intermediate workflows with 3-amino-5-bromobenzoic acid (CAS No.: 42237-85-4, CAT No.: SRCA-036). This halogenated aminobenzoic acid combines a bromo substituent and an amino group on a benzoic acid core, making it a highly versatile scaffold for cross-coupling, amide formation, and heterocycle construction in medicinal and agrochemical chemistry.

With a molecular formula of C₇H₆BrNO₂ and a molecular weight of 216.03 g/mol, 3-amino-5-bromobenzoic acid is typically obtained as an off-white to light beige crystalline solid. It offers the synthetic advantages of an electron-withdrawing bromine handle for palladium-catalyzed couplings and a nucleophilic amino group for acylation, sulfonylation, and condensation reactions, enabling efficient access to diverse bioactive analogues.

Product Highlights

Technical Features & Benefits

• • Halogenated Aminobenzoic Core: Bromine at the 5-position provides an excellent handle for Suzuki, Buchwald?Hartwig, and other Pd-catalyzed cross-coupling reactions.

• • Reactive Amino and Carboxyl Groups: The amino and carboxylic acid functions enable straightforward amide, urea, sulfonamide, and ester formation for rapid library generation.

• • Medicinal Chemistry Building Block: Frequently used as a starting material in the synthesis of bioactive small molecules and specialty benzoic acid derivatives.

• • Defined Physical Properties: Well-characterized molecular weight, formula, and melting behavior support robust analytical method development and QC.

• • Optimized for R&D: Offered at high purity, suitable for discovery chemistry, route scouting, and impurity or reference standard preparation.

Application Areas

• • Intermediate for pharmaceutical and agrochemical candidates bearing substituted anilide, benzamide, or benzimidazole motifs.

• • Building block in cross-coupling strategies to access biaryl, aryl-heterocycle, and fused-ring architectures.

• • Starting point for designing unnatural amino acid analogues and peptide/peptidomimetic modules.

• • Reference or process intermediate in impurity profiling and synthetic route optimization for brominated aromatic APIs.

• • Research compound for SAR exploration on halogenated aminobenzoic acid series in medicinal chemistry.

Safety & Handling

• • Toxic if swallowed and may cause skin and eye irritation; wear gloves, safety goggles, and lab coat during handling.

• • Handle powders in a fume hood to avoid dust generation and inhalation; ensure good ventilation in the working area.

• • Store under inert gas in a tightly closed container, protected from light and moisture, away from strong oxidizing agents.

• • Dispose of residues and contaminated materials as hazardous waste according to local and national regulations.?

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Specialized capability in halogenated aromatics, pharmaceutical intermediates, and impurity standards with stringent quality control.

• • Custom synthesis and scale-up services for brominated benzoic acids and downstream analogues from milligram to multi-kilogram scale.

• • Comprehensive analytical documentation, including COA and available NMR, HPLC, and LC?MS data tailored to your specification needs.
• Agile technical support and customer service to align material specifications, impurity profiles, and delivery schedules with your project timelines.

Request a Quote or Sample Today! Accelerate your aromatic coupling, API intermediate, and medicinal chemistry programs with SRIRAMCHEM?s premium 3-amino-5-bromobenzoic acid. Contact the expert team for pricing, availability, or to discuss custom synthesis and documentation support.