2-Mercapto-5-methoxybenzimidazole

Optimize your proton pump inhibitor impurity control with 2-mercapto-5-methoxybenzimidazole (CAS No.: 37052-78-1, CAT No.: SRCM-034). Designated as Omeprazole EP Impurity A (Related Compound B), this benzimidazole thiol serves as a critical reference standard for analytical method validation and process monitoring in omeprazole manufacturing.

With a molecular formula of C₈H₈N₂OS and a molecular weight of 180.23 g/mol, it appears as an off-white to light yellowish-brown powder with a melting point of 261?263°C. Insoluble in water but soluble in DMSO and methanol, its thione tautomer provides characteristic UV absorbance for HPLC detection.

Product Highlights

Technical Features & Benefits

• • Omeprazole EP Impurity A: Official pharmacopoeial reference standard for regulatory compliance and stability-indicating methods.

• • Thione Tautomer Marker: Characteristic UV/chromatographic profile enables trace-level detection in omeprazole formulations.

• • High Thermal Stability: Melting point 261?263?C supports robust purification and long-term reference stability.

• • Process Desulfurization Product: Key degradation byproduct from incomplete sulfone oxidation in PPI manufacturing.

• • Certified Reference Quality: ?98% HPLC purity with full characterization for ANDA/NDA submissions.

Application Areas

• • Certified reference standard for omeprazole impurity profiling (EP/USP/BP).

• • System suitability standard in HPLC/LC-MS methods for PPI quality control.

• • Synthetic intermediate for COX-2 inhibitors and benzimidazole research analogs.

• • Process validation marker for sulfone formation efficiency in omeprazole synthesis.

• • Degradation pathway research in proton pump inhibitor stability studies.

Safety & Handling

• • Potential skin/eye irritant; wear gloves, goggles, lab coat during handling.

• • Air-sensitive thione; handle under inert atmosphere (N₂) in fume hood.

• • Store refrigerated (2?8?C) in tightly closed amber containers.

• • Dispose of as pharmaceutical chemical waste per regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Specialized expertise in PPI impurities and pharmacopoeial reference standards.

• • Custom synthesis of omeprazole process impurities and degradation products.

• • Complete analytical certification: COA, NMR, HPLC, LC-MS compliant with EP/USP.

• Technical support for method validation, impurity qualification, and dossier preparation.

Request a Quote or Sample Today! Ensure omeprazole quality compliance with SRIRAMCHEM’s premium 2-mercapto-5-methoxybenzimidazole. Contact the expert team for pricing, availability, or custom reference standard requirements.