Z-Val-Cit-PAB-OH

Z-Val-Cit-PAB-OH (CAS No.: 159858-07-8, CAT No.: SRCZ-015) is a high-purity, multifunctional peptide linker fragment widely employed in antibody-drug conjugate (ADC) and targeted drug delivery research. This compound features an N-terminal Cbz (benzyloxycarbonyl, Z) protected valine–citrulline dipeptide coupled to a p-aminobenzyl (PAB) spacer and a terminal carboxylic acid. Its optimized structure enables enzymatic cleavage by cathepsin B and efficient, controlled payload release in biological systems, making it a central component in the construction of cleavable ADC linkers and advanced bioactive conjugates.

Supplied as a white to off-white solid of exceptional purity (≥98%), Z-Val-Cit-PAB-OH offers robust stability and compatibility with a range of organic solvents like DMSO, DMF, and methanol. Its molecular formula, C₂₆H₃₄N₆O₇, and molecular weight of 542.59 g/mol make it ideal for scalable synthesis, linker optimization, and analytical R&D in pharmaceutical and biotechnology labs targeting next-generation bioconjugates.

Product Highlights

Technical Features & Benefits

• Z-Val-Cit Peptide Linker: Cleavable dipeptide sequence engineered for cathepsin B-mediated site-specific ADC drug release in targeted therapy.
• PAB Spacer: Self-immolative para-aminobenzyl moiety enhances controlled payload liberation post-cleavage.
• High Purity & Stability: Stringent QC ensures reproducibility for demanding conjugation and bioanalytical workflows.
• Excellent Solubility: Compatible with major organic solvents for seamless coupling in peptide and conjugate chemistry.
• Versatile Application: Key intermediate in next-generation ADC linker payload design, bioconjugation, and chemical biology innovation projects.

Application Areas

• Synthesis and optimization of antibody-drug conjugate (ADC) linkers
• Targeted drug delivery, diagnostic conjugates, and peptide–drug conjugates (PDC)
• Bioconjugation research for controlled, enzyme-triggered payload release
• Platform development in medicinal and bioorganic chemistry
• Biological and biochemical evaluation of cleavable peptide linkers

Safety & Handling

• Handling Precautions: Use suitable personal protective equipment (gloves, goggles, lab coat). Avoid inhalation, ingestion, and contact with skin or eyes.
• Storage Recommendations: Keep tightly sealed and store at −20°C in a dry, dark environment to ensure maximal stability.
• Disposal: Dispose according to local, institutional, and regulatory requirements for laboratory chemicals.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Advanced Linker Chemistry: Global supplier specializing in high-purity cleavable peptide linkers for ADC and bioconjugate platforms.
• Full Analytical Documentation: Each batch is supplied with COA, NMR, HPLC, and MS for total quality transparency and regulatory peace of mind.
• Flexible Production & Support: From R&D to clinical scale, with responsive customer consultation and technical guidance throughout the process.
• Custom Synthesis: Tailored linker variants, conjugation protocols, and project-driven manufacturing solutions available.

Request a Quote or Sample Today!

Drive your ADC and targeted drug research with SRIRAMCHEM’s high-quality Z-Val-Cit-PAB-OH. Contact us for pricing, product samples, or custom linker solutions to elevate your next generation of conjugate therapeutics and innovations.