Z-Pro-OH

Z-Pro-OH (CAS No.: 1148-11-4, CAT No.: SRCZ-003) is a valuable N-protected proline derivative, also known as benzyloxycarbonylproline or Cbz-proline, playing a critical role as a building block in advanced peptide synthesis and medicinal chemistry. The Cbz (benzyloxycarbonyl or Z) protection on the proline nitrogen delivers reliable amino group safeguarding, enabling selective chain assembly, minimal side reactions, and flexible strategies in research and pharmaceutical projects.

Z-Pro-OH is typically supplied as a white to off-white crystalline powder of high purity (≥98%), combining excellent chemical stability with dependable performance in both manual and automated synthesis protocols. With a molecular formula of C₁₂H₁₃NO₄ and a molecular weight of 235.24 g/mol, it demonstrates strong solubility in major organic solvents such as DMSO, DMF, methanol, and ethanol, making it easy to scale from small batch research to large-scale peptide manufacturing.

Product Highlights

Technical Features & Benefits

• Czb (Cbz/benzyloxycarbonyl) Protection: Trusted N-protection strategy for precise peptide coupling and straightforward deprotection when needed.
• High Chemical Stability: Consistently reliable in both solid-phase and solution-phase synthetic techniques.
• Excellent Solubility: Compatible with most major organic solvents, supporting automated or manual peptide assembly.
• Purity & Batch Consistency: Rigorously controlled to ensure reproducible research outcomes and consistent yield in scale-up projects.
• Versatile Building Block: Ideal for peptide synthesis, medicinal chemistry, and bioconjugation work.

Application Areas

• N-protected proline for stepwise peptide synthesis (SPPS and solution-phase protocols)
• Development of pharmaceutical intermediates, analogs, and custom peptides
• Research in proteomics, bioconjugation, and fragment-based drug discovery
• Peptidomimetic and bioactive scaffold engineering

Safety & Handling

• Handling Precautions: Use standard PPE, avoid inhaling dust, and prevent prolonged contact with skin or eyes.
• Storage Recommendations: Keep container tightly closed in a cool, dry place, protected from light and moisture.
• Disposal: Dispose of in accordance with local institutional guidelines for chemical waste.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Peptide Building Block Expertise: Manufacture and supply of pure N-protected amino acids for the global research, biotech, and pharmaceutical industry.
• Certified Analytical Data: Each batch is supported by COA, NMR, HPLC, and MS data for traceability and regulatory compliance.
• Flexible Scale & Support: Options for research- and bulk-scale supply plus technical consultation for specialized synthesis needs.
• Responsive Customer Care: Guidance from inquiry to post-delivery for application success.

Request a Quote or Sample Today!

Upgrade your peptide synthesis and chemical development with SRIRAMCHEM’s high-purity Z-Pro-OH. Get in touch for pricing, sample enquiries, or custom synthesis solutions.