Z-Leu-OH

Z-Leu-OH (CAS No.: 2018-66-8, CAT No.: SRCZ-031) is a high-purity N-protected leucine derivative, widely used as a crucial building block in peptide synthesis and medicinal chemistry. Also known as benzyloxycarbonylleucine or Cbz-leucine, this compound features the classic benzyloxycarbonyl (Cbz or Z) protecting group on the amino terminus, enabling selective protection necessary for controlled peptide bond formation while minimizing side reactions in complex multi-step synthetic procedures.

Provided as a white to off-white crystalline powder with excellent purity (≥98%), Z-Leu-OH demonstrates strong chemical stability and good solubility in common organic solvents such as DMSO, DMF, and methanol. Its molecular formula is C₁₃H₂₁NO₄ and its molecular weight is 243.31 g/mol, making it suitable for both solid-phase and solution-phase peptide synthesis, supporting research, pharmaceutical development, and biotechnological applications.

Product Highlights

Technical Features & Benefits

• Trusted Cbz (Benzyloxycarbonyl) N-Protection: Provides selective protection of the amino group, enabling efficient peptide bond formation and mild deprotection.
• High Purity & Consistency: Manufactured under stringent quality control for reproducible peptide synthesis and batch-to-batch uniformity.
• Excellent Solubility: Compatible with common polar organic solvents used in solid-phase and solution-phase peptide synthesis workflows.
• Stable Crystalline Form: Offers ease of handling, reliable storage stability, and extended shelf-life when stored properly.
• Versatile Building Block: Suitable for medicinal chemistry, peptide therapeutic development, and biochemical research applications involving leucine residues.

Application Areas

• N-protected leucine for use in solid-phase and solution-phase peptide synthesis
• Intermediate for pharmaceutical peptides, peptidomimetics, and drug discovery programs
• Building block for biochemical probes and protein engineering research
• Used in fragment-based drug design and custom peptide library synthesis

Safety & Handling

• Handling Precautions: Use appropriate PPE such as gloves, goggles, and lab coat. Avoid inhalation, ingestion, and direct skin or eye contact.
• Storage Recommendations: Store tightly sealed at 2–8°C in a cool, dry, and dark environment to preserve stability and quality.
• Disposal: Dispose of chemical waste according to local, regional, and institutional safety regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Peptide Chemistry Expertise: Reliable supplier of high-purity N-protected amino acids and intermediates with stringent quality assurance.
• Comprehensive Analytical Documentation: Each batch is supplied with COA, NMR, HPLC, and MS data ensuring traceability and compliance.
• Flexible Supply & Custom Synthesis: Options ranging from research grade to bulk manufacturing with expert technical support.
• Dedicated Customer Support: Responsive assistance from inquiry to delivery and post-sales technical guidance for successful research outcomes.

Request a Quote or Sample Today!

Advance your peptide synthesis and medicinal chemistry projects with SRIRAMCHEM’s premium Z-Leu-OH. Contact us for pricing, sample availability, or custom synthesis solutions tailored to your research requirements.