Z-His-OH

Z-His-OH (CAS No.: 14997-58-1, CAT No.: SRCZ-030) is a high-purity N-protected histidine derivative, commonly referred to as benzyloxycarbonylhistidine or Cbz-histidine. This amino acid features the widely trusted benzyloxycarbonyl (Cbz or Z) protecting group on the amino terminus, ensuring selective protection for peptide synthesis and enabling efficient peptide couplings with minimized side reactions in complex multi-step protocols. Z-His-OH is an indispensable building block for modern peptide chemistry and drug discovery, facilitating precise incorporation of histidine residues in bioactive peptides and protein analogs.

Supplied as a white to off-white crystalline powder with excellent purity (≥98%), Z-His-OH demonstrates robust chemical stability and favorable solubility in standard peptide synthesis solvents such as DMSO, DMF, and methanol. The molecular formula is C₁₄H₁₅N₃O₄ and the molecular weight is 289.29 g/mol, making it ideal for use in both solid-phase and solution-phase peptide synthesis, as well as scale-up for pharmaceutical and biotechnological research.

Product Highlights

Technical Features & Benefits

• Cbz (Benzyloxycarbonyl) Protection: Provides highly selective N-terminal protection for rapid and reliable peptide chain assembly and straightforward deprotection.
• High Purity and Analytical Consistency: Meets rigorous standards for repeatable, high-yield peptide synthesis and scalable research needs.
• Excellent Solubility Profile: Easily dissolved in standard peptide solvents, suitable for both automated and manual synthesis methods.
• Batch-to-Batch Reliability: Carefully manufactured to ensure chemical stability and reproducible outcomes in research and production environments.
• Versatile Synthetic Utility: Critical for peptide therapeutics, structural studies, and protein engineering where histidine residues play a key functional role.

Application Areas

• N-protected histidine for solid-phase and solution-phase peptide synthesis
• Intermediate in medicinal chemistry, peptidomimetic research, and structure–activity studies
• Platform for developing enzymatic substrates, bioconjugates, and therapeutic peptides
• Fragment-based drug design and construction of custom peptide libraries

Safety & Handling

• Handling Precautions: Use appropriate laboratory protective equipment (gloves, goggles, lab coat). Avoid inhalation, ingestion, and contact with skin or eyes.
• Storage Recommendations: Store in tightly closed containers at 2–8°C, protected from light and moisture to maintain integrity and shelf life.
• Disposal: Dispose of chemical waste in accordance with local, regional, and institutional regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Peptide Chemistry Expertise: Trusted global provider of high-purity N-protected amino acids and peptide building blocks, supported by robust analytical documentation.
• Comprehensive Quality Control: Every batch supplied with COA, NMR, HPLC, and MS to guarantee regulatory compliance and quality transparency.
• Flexible Supply & Custom Synthesis: Options for research to commercial scale, with responsive technical support and tailored services.
• Dedicated Customer Service: Reliable technical and order support from inquiry through delivery for ongoing project success.

Request a Quote or Sample Today!

Advance your peptide synthesis, drug discovery, and research workflows with SRIRAMCHEM’s premium Z-His-OH. Contact us for pricing, sample availability, or project-specific custom synthesis solutions.