VH298

VH298 (CAS No.: 2097381-85-4, CAT No.: SRCV-003) is a highly potent, cell-permeable, and selective small-molecule inhibitor of the E3 ubiquitin ligase Von Hippel-Lindau (VHL). VH298 disrupts the interaction between VHL and hydroxylated HIF-α (hypoxia-inducible factor alpha), thereby stabilizing HIF-α and triggering a hypoxia-mimetic cellular response in normoxic conditions. This chemical probe is widely used in chemical biology and medicinal research to study the hypoxic signaling cascade and explore new pathways for therapeutic intervention.

VH298 exhibits nanomolar affinity for VHL (K_d = 80–90 nM), resulting in time- and concentration-dependent accumulation of hydroxylated HIF-α and upregulation of HIF target gene transcription at mRNA and protein levels. Studies indicate its application in wound healing, angiogenesis, and the modulation of cell proliferation, making it an attractive starting point for developing new hypoxia-activated therapeutics and investigative probes for cellular hypoxic responses.

Product Highlights

Technical Features & Benefits

• Potent VHL E3 Ligase Inhibitor: Blocks VHL:HIF-α interaction with high affinity (K_d = 80–90 nM), leading to HIF-α stabilization.
• Selective Hypoxia-Mimetic: Induces upregulation of HIF-dependent target genes, mimicking cellular hypoxia.
• Versatile Research Tool: Used in wound healing, angiogenesis, cell signaling, and hypoxia pathway studies.
• Cell Permeable and High Purity: Suitable for cellular, biochemical, and in vivo applications.
• Stable and Easy to Handle: Solid form with robust shelf life and reliable performance in research workflows.

Application Areas

• Chemical probe for hypoxia signaling and cellular oxygen sensing
• Study of E3 ubiquitin ligase and protein-protein interactions
• Wound healing and angiogenesis models
• Drug discovery, PROTAC development, and molecular pharmacology
• Metabolic, cancer, and cardiovascular disease research

Safety & Handling

• Handling Precautions: Use gloves, goggles, and laboratory coat. Avoid inhalation, ingestion, and contact with skin or eyes.
• Storage Recommendations: Store at -20°C in a tightly sealed container, protected from light and moisture.
• Disposal: Dispose of in accordance with institutional and regional chemical regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• High-Quality Research Chemicals: Stringent QC, full analytical documentation, and reproducibility.
• Custom Synthesis & Scale-Up: Flexible production for research and pharmaceutical development.
• Comprehensive Analytical Support: COA, NMR, HPLC, and MS data supplied with every batch.
• Expert Customer Service: Technical guidance from inquiry to delivery for all your research needs.

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Advance your hypoxia and signaling pathway research with SRIRAMCHEM’s premium VH298. Contact us for pricing, sample availability, or custom synthesis requests.