trans-4,5-Dihydroxy-1,2-dithiane (Oxidised DTT)

Advance your biochemical and synthetic research with trans-4,5-Dihydroxy-1,2-dithiane, also known as oxidised dithiothreitol (DTT) (CAS No.: 14193-38-5, CAT No.: SRCD-027). This compound is the oxidised disulfide form of DTT, featuring a six-membered dithiane ring with trans-configured hydroxyl groups at positions 4 and 5. It plays a crucial role in redox biology and protein chemistry by serving as the oxidised counterpart in thiol-disulfide exchange reactions.

The compound has a molecular formula of C₄H₈O₂S₂ and a molecular weight of approximately 152.23 g/mol. It usually appears as a white to off-white crystalline solid and is soluble in polar organic solvents such as DMSO and DMF, facilitating its use in biochemical assays and synthetic workflows.

Product Highlights

Technical Features & Benefits

• Oxidised Disulfide Form: Serves as the oxidised counterpart of dithiothreitol (DTT), crucial in redox reactions and thiol-disulfide exchange systems.
• Trans-Configuration: The hydroxyl groups are positioned trans on the dithiane ring, impacting its chemical and biochemical behavior distinct from the cis isomer.
• High Purity: Manufactured with rigorous quality controls for consistency and reproducibility in biochemical assays.
• Solvent Compatibility: Readily soluble in polar organic solvents facilitating use in protein chemistry, enzymology, and analytical workflows.
• Redox Biology Applications: Widely used to study disulfide bond formation, oxidative folding, and protein thiol status.

Application Areas

• Biochemical and enzymatic studies involving thiol-disulfide exchange reactions.
• Protein chemistry for investigating disulfide bond formation and folding.
• Analytical assays requiring stable oxidised thiol reagents.
• Redox biology and oxidative stress research.
• Complementary reagent to reduced DTT in experimental protocols.

Safety & Handling

• Precautions: Use appropriate personal protective equipment (gloves, lab coat, safety glasses). Avoid ingestion, inhalation, and skin or eye contact.
• Storage: Store tightly sealed in a cool, dry, well-ventilated place away from light and moisture to maintain stability.
• Disposal: Dispose of chemical waste according to local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Our advanced facilities and experienced team guarantee high purity and precise production. Since 2013, SRIRAMCHEM has supported pharmaceutical innovation and biochemical research worldwide.
• Custom Synthesis: Flexible production from milligram to multi-kilogram scales tailored to your precise project needs.
• Comprehensive Documentation: Every batch includes detailed Certificates of Analysis (COA), NMR, LC-MS, and HPLC data to ensure identity and quality.
• Customer-Focused Support: We prioritize collaborative partnerships and responsive service, supporting your scientific goals from inquiry through delivery.

Request a Quote or Sample Today!
Accelerate your biochemical, enzymatic, and synthetic research with SRIRAMCHEM’s premium trans-4,5-Dihydroxy-1,2-dithiane (Oxidised DTT). Contact our expert team now for pricing, sample availability, or custom synthesis services.