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TOFA has been used as a lipid biosynthesis inhibitor in mesenchyme stromal cells (MSCs),[1] human pluripotent stem cells.[2], an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines.[3], a lipolysis inhibitor in cancer stem cells (CSCs).[4]

TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells[5].

Weibo Zhou et al.

Cancer research, 63(21), 7330-7337 (2003-11-13)

C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer cells. Its proposed mechanism of action linked high levels of malonyl-CoA after FAS inhibition to potential downstream effects including inhibition of carnitine palmitoyltransferase-1 (CPT-1) with resultant

2.Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication.

P T Lange et al.

mBio, 9(4) (2018-07-19)

Gammaherpesviruses are oncogenic pathogens that persist in ~95% of the adult population. Cellular metabolic pathways have emerged as important regulators of many viral infections, including infections by gammaherpesviruses that require several lipid synthetic pathways for optimal replication. Liver X receptors

3. Inhibition of fatty acid synthesis induces apoptosis of human pancreatic cancer cells

Nishi K, et al.

Anticancer Research, 36(9), 4655-4660 (2016)

4. Fanconi anemia mesenchymal stromal cells-derived glycerophospholipids skew hematopoietic stem cell differentiation through toll-like receptor signaling

Amarachintha S, et al.

Stem Cells, 33(11), 3382-3396 (2015)

5.Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome

Cramer CT, et al.

Journal of Lipid Research, 45(7), 1289-1301 (2004)