MC-Val-Cit-PAB-OH

Advance your bioconjugation, ADC (antibody-drug conjugate) research, and peptide linker development with MC-Val-Cit-PAB-OH (CAS No.: 159857-80-4, CAT No.: SRCM-014). This compound is a highly specialized cleavable peptide linker consisting of a maleimide (MC) group, a valine-citrulline dipeptide motif (Val-Cit), and a p-aminobenzyl alcohol (PAB-OH) self-immolative spacer. It is explicitly designed for targeted drug delivery systems—especially in the synthesis of ADCs, where site-specific release is triggered by cathepsin B cleavage.

The molecular formula is C₂₈H₄₀N₆O₇ and the molecular weight is approximately 572.7 g/mol. MC-Val-Cit-PAB-OH appears as a white to almost white solid or crystalline powder. For optimum stability, it should be stored under inert gas, protected from light, moisture, and heat, preferably at −20 °C.

Product Highlights

Technical Features & Benefits

• Cleavable Peptide Linker: Designed for selective cathepsin B cleavage, enabling site-specific and controlled drug release in ADCs.
• Maleimide (MC) Group: Provides high reactivity with thiol-containing biomolecules for stable conjugation.
• PAB Self-Immolative Spacer: Enables efficient, traceless release of attached cytotoxic payloads following enzymatic cleavage.
• High Purity: Manufactured to rigorous standards (≥98% by HPLC), ensuring high coupling yields.
• Research and GMP Grades Available: Suitable for preclinical, clinical, and commercial ADC development.

Application Areas

• Antibody-drug conjugate (ADC) linker synthesis
• Development of targeted drug delivery systems and payload release strategies
• Bioconjugation workflows in cancer therapeutics
• Synthesis of cleavable linkers for small-molecule–macromolecule conjugates
• Pharmaceutical research and development of enzyme-cleavable constructs

Safety & Handling

• Use appropriate personal protective equipment: gloves, lab coat, eye protection
• Avoid exposure to light, moisture, and heat
• Store under inert gas at −20 °C in a tightly sealed container
• Dispose of chemical waste according to regional and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expertise in peptide and linker chemistry with strict quality control ensuring batch reproducibility
• Comprehensive analytical documentation (COA, NMR, HPLC, LC-MS) provided with every batch
• Custom synthesis and scale-up services for research, preclinical, clinical, and GMP supply
• Dedicated technical and customer support optimized for bioconjugation and ADC development

Request a Quote or Sample Today!
Drive your ADC and targeted therapy research forward with SRIRAMCHEM’s premium MC-Val-Cit-PAB-OH. Contact our expert team for pricing, technical documentation, or custom synthesis inquiries.