Isopropyl-Alaninate HCl

Strengthen your peptide synthesis, amino acid chemistry, and pharmaceutical research with Isopropyl-Alaninate HCl (CAS No.: 62062-65-1, CAT No.: SRCI-013). Also known as L-alanine isopropyl ester hydrochloride or (S)-2-aminopropionic acid isopropyl ester hydrochloride, this derivative features a protected carboxyl group as an isopropyl ester and a free amino group in the hydrochloride salt form. It is widely used in the synthesis of peptides, anti-viral prodrugs, and as a building block in medicinal chemistry.

The ester function provides enhanced reactivity and solubility, while the HCl salt ensures stability and easy handling in aqueous systems. Isopropyl-Alaninate HCl is compatible with various coupling and protection strategies, enabling its use in both solution-phase and solid-phase peptide synthesis.

Molecular formula: C₆H₁₄ClNO₂, Molecular weight: 167.63 g/mol. It appears as a white to orange or green solid/crystalline powder, melting point 85 °C, with specific rotation +1° to +3° (c = 2, MeOH). The compound is highly soluble in water, slightly soluble in DMSO and methanol, and is very hygroscopic (absorbs atmospheric moisture). For highest stability and purity (≥98%), store at room temperature (<15°C for long term), sealed from moisture and light, ideally under inert gas.

Product Highlights

Technical Features & Benefits

• High Purity (≥98%): Suitable for high-precision peptide synthesis or API manufacture.
• Stable Ester Protection: Isopropyl ester prevents undesired main-chain reactions in solid/small-molecule coupling.
• Hydrochloride Salt: Improves water solubility and storage stability, reduces volatility during handling.
• Stereochemically Pure: L-configuration, matches natural alanine for effective integration in peptide/protein synthesis.
• Utility as a Synthetic Reagent: Used in anti-HCV prodrug synthesis, peptide drug discovery, and protease substrate design.

Application Areas

• Peptide synthesis via solution or solid-phase chemistry
• Building block for peptidomimetics, prodrugs, and bioconjugates
• Intermediate in anti-viral and specialty chemical synthesis
• Bioanalytical research, structure-activity studies

Safety & Handling

• Precautions: Use standard lab PPE (gloves, goggles, coat). Avoid ingestion or direct skin/eye contact. Highly hygroscopic; open only under dry air or inert conditions.
• Storage: Keep tightly sealed, in a desiccator, and away from light at cool temperature. Store under inert gas if possible.
• Disposal: Dispose of in accordance with local and national regulations for amino acid derivatives and laboratory chemicals.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Strict QC, high purity, and reliable supply chain since 2013.
• Full Documentation: Supplied with Certificate of Analysis (COA), NMR, and purity data for each batch.
• Knowledgeable Support: Responsive technical and customer assistance for scientific and commercial projects.
• Custom Synthesis Available: Bulk or specific packing to client R&D or commercial needs.

Request a Quote or Sample Today!
Enhance your research with SRIRAMCHEM’s Isopropyl-Alaninate HCl. Contact us for current pricing, samples, or technical support.