Isonicotinic acid

Optimize your pharmaceutical synthesis, catalysis, and crystal engineering with Isonicotinic acid (CAS No.: 55-22-1, CAT No.: SRCI-018). Also known as pyridine-4-carboxylic acid or 4-picolinic acid, this compound is an isomer of nicotinic and picolinic acids, featuring a carboxyl group at the 4-position of a pyridine ring. Isonicotinic acid is highly regarded as an intermediate in the production of pharmaceuticals (notably anti-TB agents like isoniazid), agrochemicals, coordination complexes, and as an organocatalyst in heterocyclic synthesis. It is a valuable co-crystal former due to strong hydrogen-bonding capacity and is widely used in the preparation of supramolecular structures, MOFs (metal-organic frameworks), and as an organic ligand in complexation chemistry.

Molecular formula: C₆H₅NO₂, Molecular weight: 123.11 g/mol. Appearance: white to light yellow crystalline powder or needles, odorless, sublimable. Melting point: 315–319 °C (decomp.), with some references reporting >300 °C and up to 319 °C. Boiling point: 260 °C (15 mmHg). Density: 1.47 g/cm³. Moderately soluble in hot water (5–6 g/L at 20°C), only slightly in cold water; insoluble in alcohol, ether, benzene. Amphoteric, pKa ≈ 4.96 at 25°C. Stable to heat and oxidation. Purity: ≥99% (HPLC, TCI standard).

Product Highlights

Technical Features & Benefits

• Pharmaceutical Precursor: Key for isoniazid, ethionamide, and metal coordination complexes.
• Catalyst & Ligand: Organocatalyst in heterocycle construction and robust chelator in MOF and complex design.
• Strong Hydrogen Bonding: Ideal for crystal engineering and co-crystal formation with APIs and fine chemicals.
• Stable & High Purity: Minimal decomposition, reliable for multi-step syntheses and analytical standards.
• Plant & Human Metabolite: Used in metabolic studies as a biologically relevant pyridinecarboxylic acid.

Application Areas

• Pharmaceutical intermediate (isoniazid, isoniazid hydrazide, ethionamide synthesis)
• Agrochemical and heterocycle manufacturing
• Ligand in metal-organic frameworks and polymer science
• Organocatalysis, multi-component, and condensation reactions
• Crystallography and co-crystal design (API solubility improvement)

Safety & Handling

• Hazard: Causes serious eye and skin irritation (H319, H315). Use gloves, goggles, lab coat. Avoid dust formation and direct contact.
• First Aid: Rinse thoroughly with water if in eyes or on skin; seek medical advice if irritation persists.
• Storage: Store in a tightly sealed container, protected from moisture and light, at cool room temperature (<15°C for long-term stability).
• Disposal: Dispose in accordance with local and national chemical regulations as a laboratory organic acid.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Industry-Leading Quality: High-purity, analytically confirmed isonicotinic acid since 2013.
• Batch Flexibility: Available from grams to multi-kilogram scale for R&D or manufacturing.
• Documentation: Certificate of Analysis (COA) and SDS provided with each batch.
• Rapid Technical Support: Responsive team for documentation, regulatory, and technical queries.

Request a Quote or Sample Today!
Enhance your synthesis and process workflows with SRIRAMCHEM’s Isonicotinic acid—contact us for pricing, samples, or custom sourcing solutions.