Isonicotinamide

Advance your pharmaceutical, analytical, and synthetic research with Isonicotinamide (CAS No.: 1453-82-3, CAT No.: SRCI-016). Also known as pyridine-4-carboxamide, this compound is an isomeric analog of nicotinamide (vitamin B3 metabolite), valued for its utility as a pharmaceutical intermediate, co-crystal former, and heterocyclic building block. It is a white to almost white crystalline powder with high purity (≥99%), widely used in the synthesis of anti-tubercular agents, organotin complexes, and as a metabolite in biochemical pathways. Isonicotinamide shows strong hydrogen bonding, making it useful in crystal engineering and the design of co-crystals to improve drug properties.

It is also a potent apoptosis inducer in certain cancer cell lines and is explored in material science and coordination chemistry. Molecular formula: C₆H₆N₂O, Molecular weight: 122.13 g/mol. Appearance: white to off-white crystalline powder. Melting point: 155–158 °C. Boiling point (estimate): 227–334 °C. Density: approx. 1.22 g/cm³. Highly soluble in water (191.7 g/L at 37°C), slightly soluble in methanol and DMSO. LogP: –0.28 (hydrophilic). Store at room temperature in a cool, dark, and dry location (<15°C recommended) for best stability. Purity (HPLC): min. 99%.

Product Highlights

Technical Features & Benefits

• Pharmaceutical Intermediate: Key synthon for anti-tuberculars, APIs, and co-crystal formers for enhanced drug solubility/bioavailability.
• Versatile Building Block: Enables the synthesis of complex heterocycles, metal complexes, and fine chemicals.
• Strong Hydrogen Bonding: Excellent for co-crystal engineering and supramolecular chemistry.
• Excellent Water Solubility: Facilitates formulation and compatibility with aqueous systems.
• High Stability and Purity: Reliable storage and handling with minimal decomposition or impurities.

Application Areas

• Intermediate in API and pharmaceutical synthesis (anti-tuberculars, pyridine derivatives)
• Co-crystallization agent to improve drug properties
• Building block in heterocyclic, coordination, and material chemistry
• Fine chemical, agrochemical, and biochemical R&D

Safety & Handling

• Hazards: Causes skin and serious eye irritation. Avoid inhalation or skin/eye contact. Use PPE (gloves, goggles, lab coat). Avoid release to environment and runoff.
• First Aid: Rinse thoroughly with water if in eyes or on skin. Seek medical advice if irritation persists.
• Storage: Cool, dry, well-sealed containers; avoid moisture and direct sunlight. Store below 15°C for longest shelf-life.
• Disposal: Dispose according to local/national chemical waste regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Quality Assurance: High-purity, analytically verified batches with each order.
• Expert Synthesis & Supply: Reliable source for milligram-to-kilogram scale with responsive technical support.
• Comprehensive Documentation: Certificate of Analysis (COA), MSDS, and QC data available for each lot.
• Supportive Team: Technical and logistic assistance at every stage of your research project.

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