Indole-3-carbonitrile

Drive your pharmaceutical, agrochemical, and advanced synthetic research with Indole-3-carbonitrile (CAS No.: 5457-28-3, CAT No.: SRCI-009). Also known as 3-cyanoindole, this compound features a cyano group at the 3-position of an indole core, enhancing its reactivity and making it a key intermediate for building complex indole derivatives. Indole-3-carbonitrile is widely used in the synthesis of tryptophan-based compounds, β-lactams, kinase inhibitors, antiviral agents, and numerous other bioactive molecules. Its structure allows for efficient regioselective C–H functionalization, cross-coupling, and heterocycle formation. The molecule is essential for the development of new pharmaceutical scaffolds, dye chemistry, and specialized ligands in material science.

Molecular formula: C₉H₆N₂, Molecular weight: 142.16 g/mol. Appearance: White to light yellow or light orange powder or crystals. Melting point: 179–182 °C. It is sparingly soluble in chloroform and methanol, insoluble in water, and sensitive to light and air. For long-term stability, store sealed in a dry, cool, dark place under inert gas. Purity: ≥98%.

Product Highlights

Technical Features & Benefits

• Cyano-Activated Scaffold: Ideal for C–H activation, nucleophilic addition, and cyclization reactions.
• Key Intermediate: Used in the synthesis of biologically active indoles, kinase/antitumor/antiviral agents, and custom molecular targets.
• High Purity & Stability: Batch-to-batch consistency supports analytical and process scale synthesis.
• Ready for Functionalization: Suitable for cross-coupling and heterocycle construction techniques.

Application Areas

• Synthesis of pharmaceuticals, kinase inhibitors, and β-lactam antibiotics
• Agrochemical and dye intermediate
• Research in new heterocycles and scaffold-hopping chemistry
• Fragment-based ligand and drug design in medicinal chemistry

Safety & Handling

• Precautions: Harmful if ingested, in contact with skin, or inhaled. Irritating to skin and eyes. Use personal protective equipment—gloves, goggles, lab coat; avoid inhalation and direct contact.
• Storage: Keep in tightly sealed container in cool, dry, dark location under inert gas. Protect from air and light.
• Disposal: Dispose in compliance with local and national environmental regulations as hazardous organic chemical waste.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Intermediate Manufacturing: Numerous indole derivatives produced with consistent high purity since 2013.
• Custom Synthesis: Flexible order size from research milligrams to industrial multi-kilogram quantities.
• Comprehensive Analysis: COA and detailed analytical data for every batch.
• Dedicated Support: Responsive scientific and logistics help for your next research or production project.

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Advance your complex molecule synthesis with SRIRAMCHEM’s Indole-3-carbonitrile. Contact us for pricing, technical details, or custom solution requests.