HATU

Drive highly efficient peptide bond formation and advanced organic synthesis with HATU (CAS No.: 148893-10-1, CAT No.: SRCH-021). HATU (O-(7-Azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate) is a premier coupling reagent for solid-phase and solution-phase peptide synthesis. It is especially renowned for rapid amide bond formation, high yields with difficult sequences, and minimal racemization. HATU readily reacts with carboxylic acids in the presence of an organic base (such as DIPEA) to generate activated OAt esters, accelerating acylation of both amines and alcohols. Its high reactivity is a result of the neighbouring group effect from the azabenzotriazole moiety, which facilitates the critical transition state for amide formation. HATU is soluble in DMF and other polar aprotic solvents, and is routinely used in Boc and Fmoc peptide synthesis protocols as well as in cyclization and fragment condensation chemistry.

Molecular formula: C₁₀H₁₅F₆N₆OP, Molecular weight: 380.24 g/mol. It is supplied as a white to off-white crystalline powder, >98% purity, and should be stored in a dry, cool place for optimal stability.

Product Highlights

Technical Features & Benefits

• Highly Efficient Coupling: Rapid and high-yielding peptide bonds for both solid-phase and solution-phase synthesis.
• Low Racemization: Ensures chiral purity even in challenging amino acid sequences.
• Versatile Applications: Useful in the synthesis of simple peptides, difficult b-branched/N-methyl peptides, peptide cyclization, fragment coupling, and oligonucleotide chemistry.
• Broad Compatibility: Works with both Boc and Fmoc chemistry protocols and in a wide range of organic solvents.

Application Areas

• Solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis (LPPS).
• Acylation reactions in complex small-molecule and natural product synthesis.
• Synthesis of β-amino alcohols, peptide alcohols, and macrocycles.
• Automated synthesis of complicated peptide/oligonucleotide conjugates.

Safety & Handling

• Precautions: Use appropriate PPE (gloves, goggles, lab coat). Avoid inhalation, ingestion, or skin contact. Employ adequate ventilation when handling powders.
• Storage: Store in tightly sealed containers in a cool, dry place, away from moisture and incompatible materials.
• Disposal: Dispose of in accordance with local and national chemical waste regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: High-purity peptide reagents synthesized and quality-assured in advanced facilities, supporting researchers since 2013.
• Custom Synthesis: Scalable solutions and custom packaging from milligrams to multi-kilograms.
• Complete Documentation: Each batch is accompanied by COA and advanced analytical data (NMR, LC-MS, HPLC).
• Dedicated Customer Support: Responsive and collaborative service for all research, pilot, and commercial needs.

Request a Quote or Sample Today!
Accelerate your peptide synthesis and research workflow with SRIRAMCHEM’s top-tier peptide coupling reagents. Contact us for pricing, samples, or bulk custom synthesis.