H-Thr(tBu)-OtBu

Advance your peptide synthesis with H-Thr(tBu)-OtBu (CAS No.: 5854-78-4, CAT No.: SRCT-028), a double tert-butyl protected form of L-threonine. This derivative features tert-butyl protection on both the hydroxyl and carboxyl groups, making it an essential orthogonally protected building block for solid-phase and solution-phase peptide synthesis. The dual protection facilitates selective deprotection and precise peptide chain assembly while minimizing side reactions involving the threonine side chain.

H-Thr(tBu)-OtBu is supplied as a clear to slightly yellowish liquid or low-melting solid with high purity (≥96–98%). It demonstrates robust stability and is readily soluble in organic solvents such as DMSO and DMF. Its consistent batch quality and straightforward integration into synthetic protocols make it ideal for pharmaceutical research, peptide libraries, and the synthesis of complex bioactive peptides.

Product Highlights

Technical Features & Benefits

• Dual tert-Butyl Protection: Provides orthogonal protection for both side-chain hydroxyl and carboxyl groups, simplifying complex synthetic strategies.
• High Purity & Reproducibility: Consistent product quality ensures reliable and efficient peptide syntheses.
• Optimized Solubility: Easily dissolves in common peptide synthesis solvents for seamless process integration.
• Stability & Storage: Robust under cold, dry, dark conditions; suitable for long-term storage.
• Versatility: Applicable for peptide, peptidomimetic, and advanced bioactive compound synthesis.

Application Areas

• Solid-phase and solution-phase peptide synthesis with orthogonal protection
• Combinatorial chemistry and peptide library construction
• Pharmaceutical and biochemical synthesis involving threonine residues
• Research on protecting group strategies and new peptide analogues

Safety & Handling

• Handling Precautions: Use gloves, goggles, and appropriate lab attire. Avoid inhalation, ingestion, and skin or eye contact.
• Storage Recommendations: Store in tightly sealed containers at −20°C, dry, and protected from light.
• Disposal: Dispose of in accordance with institutional and environmental regulations for laboratory chemicals.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Peptide Chemistry Expertise: Supplying orthogonally protected amino acids for reliable and efficient peptide assembly.
• Custom Synthesis & Flexible Scaling: Batch sizes tailored for research and industry with strict quality assurance (QA).
• Comprehensive Analytical Data: Full COA, NMR, HPLC, and MS documentation for every lot.
• Technical Support: Customer service from inquiry to delivery, plus synthesis consultation as needed.

Request a Quote or Sample Today!

Empower your peptide research with SRIRAMCHEM’s high-quality H-Thr(tBu)-OtBu. Contact us for pricing, sample availability, or custom synthesis solutions.