H-His(Trt)-OH

Advance your peptide synthesis and medicinal chemistry research with H-His(Trt)-OH (CAS No.: 35146-32-8, CAT No.: SRCH-002). This compound is L-histidine with the imidazole side chain protected by a trityl (Trt) group, and a free amino terminus (unprotected). It serves as a valuable intermediate for solid-phase and solution-phase peptide synthesis, enabling selective side-chain protection to prevent undesired side reactions during peptide assembly.

The compound has a molecular formula of C₂₆H₂₉N₃O₂ and a molecular weight of approximately 423.53 g/mol. H-His(Trt)-OH typically appears as a white to off-white crystalline powder, soluble in common peptide synthesis solvents such as dimethylformamide (DMF), dichloromethane (DCM), and dimethyl sulfoxide (DMSO), allowing efficient coupling in peptide synthesis protocols.

Product Highlights

Technical Features & Benefits

• Trityl (Trt) Side Chain Protection: Protects the reactive imidazole group of histidine, preventing side reactions during peptide synthesis and allowing selective deprotection under mild acidic conditions.
• Free Amino Group: Provides an unprotected N-terminus for flexible peptide chain elongation and modifications.
• High Purity & Consistency: Produced under stringent quality control to guarantee reproducible peptide synthesis and coupling efficiency.
• Excellent Solvent Compatibility: Soluble in commonly used peptide synthesis solvents, enabling seamless integration into automated and manual protocols.
• Versatile Peptide Intermediate: Applicable for the synthesis of peptides, proteins, and peptide conjugates with controlled histidine side-chain protection.

Application Areas

• Use in solid-phase and solution-phase peptide synthesis requiring selective histidine side-chain protection.
• Preparation of bioactive peptides and proteins containing histidine residues.
• Medicinal chemistry and pharmaceutical research involving modified peptides with histidine functionalities.
• Study of peptide-protein interactions, enzyme substrates, and receptor binding.
• Development of peptide-based therapeutics and diagnostic probes.

Safety & Handling

• Use appropriate personal protective equipment: gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and contact with skin or eyes.
• Store tightly sealed in a cool, dry, well-ventilated area protected from moisture and light.
• Dispose of chemical wastes according to local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• High-quality manufacturing ensuring ≥98% purity and batch-to-batch consistency since 2013.
• Comprehensive batch documentation including Certificate of Analysis (COA), NMR, HPLC, and LC-MS.
• Custom synthesis and scale-up services tailored to peptide synthesis and pharmaceutical research needs.
• Responsive technical support and dedicated customer service to assist throughout your research lifecycle.

Request a Quote or Sample Today!
Enhance your peptide synthesis and medicinal chemistry research with SRIRAMCHEM’s premium H-His(Trt)-OH. Contact our expert team for pricing, sample availability, or custom synthesis inquiries.