H-His-OMe·2HCl

Advance your peptide synthesis and medicinal chemistry research with H-His-OMe·2HCl (CAS No.: 7389-87-9, CAT No.: SRCH-013). Also known as L-Histidine methyl ester dihydrochloride, this compound features the methyl ester of L-histidine stabilized as a dihydrochloride salt. It serves as a valuable intermediate for peptide synthesis, providing a protected carboxyl terminus and easily deprotectable groups, ensuring efficient coupling and sequence fidelity.

The molecule has a molecular formula of C₇H₁₃Cl₂N₃O₂ and a molecular weight of approximately 242.10 g/mol. It typically appears as a white to almost white crystalline powder with a melting point around 207 °C (decomposition). The compound is soluble in water and common peptide synthesis solvents like dimethylformamide (DMF).

Product Highlights

Technical Features & Benefits

• Methyl Ester Dihydrochloride Salt: Stabilizes the amino acid for improved shelf life and controlled deprotection.
• High Purity: Manufactured under strict quality control ensuring ≥98% purity and reliable coupling efficiency.
• Versatile Peptide Intermediate: Ideal for solid-phase and solution-phase peptide synthesis requiring protected histidine residues.
• Good Solubility: Soluble in peptide synthesis solvents facilitating straightforward incorporation into synthesis protocols.
• Consistent Quality: Supplied with full analytical documentation including Certificate of Analysis (COA), NMR, and HPLC.

Application Areas

• Intermediate in the synthesis of peptides and peptidomimetics containing histidine
• Use in medicinal chemistry and pharmaceutical research for bioactive peptides
• Preparation of peptide libraries and synthetic proteins
• Biochemical studies involving histidine residues and their modifications
• Drug discovery and development involving targeted peptide therapeutics

Safety & Handling

• Use appropriate personal protective equipment such as gloves, lab coat, and safety glasses
• Avoid inhalation, ingestion, and skin/eye contact
• Store in a sealed container in a cool, dry, well-ventilated place protected from moisture and light
• Dispose chemical waste according to applicable regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with stringent quality assurance ensuring consistent high purity and batch reproducibility since 2013
• Comprehensive analytical documentation provided with every batch
• Custom synthesis and scalability options tailored to your research requirements
• Responsive customer service and technical support throughout your project lifecycle

Request a Quote or Sample Today!
Enhance your peptide synthesis and medicinal chemistry research with SRIRAMCHEM’s premium H-His-OMe·2HCl. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.