H-Glu(OtBu)-OtBu·HCl

Advance your peptide synthesis and medicinal chemistry research with H-Glu(OtBu)-OtBu·HCl (CAS No.: 32677-01-3, CAT No.: SRCG-005). This compound is the hydrochloride salt of L-glutamic acid with both carboxyl groups protected as tert-butyl (OtBu) esters and the free amino group stabilized as a hydrochloride salt. It serves as a valuable intermediate for peptide coupling, solid-phase and solution-phase peptide synthesis, and biochemical studies requiring protected glutamic acid derivatives with enhanced stability and reactivity.

The molecular formula is C₁₁H₂₁NO₆·HCl and the molecular weight is approximately 287.75 g/mol. H-Glu(OtBu)-OtBu·HCl typically appears as a white to off-white crystalline solid. It is soluble in common organic solvents such as methanol, ethanol, dichloromethane, and dimethylformamide, enabling flexible synthetic applications and incorporation in diverse peptide synthesis workflows.

Product Highlights

Technical Features & Benefits

• Hydrochloride Salt Form: Improves compound stability and ease of handling by stabilizing the amino group.
• Dual tert-Butyl Ester Protection: Both α- and γ-carboxyl groups are masked as OtBu esters, preventing premature side reactions in peptide synthesis and increasing chemical stability during coupling reactions.
• High Purity & Quality: Manufactured under stringent quality control to ensure consistent reactivity and reproducibility.
• Excellent Solubility: Compatible with multiple organic solvents commonly used in peptide synthesis and organic synthesis protocols.
• Versatile Intermediate: Used extensively in solid-phase and solution-phase peptide synthesis, especially for glutamic acid residue incorporation with side chain protection.

Application Areas

• Intermediate for protected glutamic acid residue incorporation in solid-phase and solution-phase peptide synthesis (SPPS and LPPS).
• Used in medicinal chemistry and pharmaceutical research for synthesis of bioactive peptides and analogues.
• Facilitates coupling reactions with improved stability and minimized side reactions.
• Research in peptide engineering, structural biology, and development of peptide-based therapeutics.
• Utility in organic synthesis requiring protected carboxyl groups and amine stabilization.

Safety & Handling

• Wear appropriate personal protective equipment including gloves, lab coat, and safety goggles.
• Avoid inhalation, ingestion, and direct contact with skin or eyes.
• Store the product sealed in a cool, dry, well-ventilated area, protected from moisture, heat, and light.
• Dispose of chemical waste in accordance with local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing ensuring high purity and batch-to-batch consistency since 2013.
• Reliable supply of research-grade protected glutamic acid derivatives with full analytical documentation including COA, NMR, HPLC, and LC-MS.
• Custom synthesis and scalable production tailored to peptide synthesis and pharmaceutical development requirements.
• Dedicated technical support and responsive customer service throughout your research and development projects.

Request a Quote or Sample Today!
Advance your peptide synthesis and medicinal chemistry applications with SRIRAMCHEM’s premium H-Glu(OtBu)-OtBu·HCl. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.