H-Cys(tBu)-OtBu

Enhance your peptide synthesis and research in advanced biochemical applications with H-Cys(tBu)-OtBu (CAS No.: 76587-61-6, CAT No.: SRCC-018). This specialized cysteine derivative features both tert-butyl and S-tert-butyl protecting groups on the amino acid Cys, offering reliable thiol and carboxyl protection during solid-phase peptide synthesis (SPPS) and other custom synthetic protocols. The dual-protection strategy helps minimize side reactions, oxidation, and racemization, delivering consistent yields and purity in your peptide workflow.

With a molecular formula of C₂₆H₂₉NO₂S and molecular weight of 419.59 g/mol, it is typically provided as a white to off-white crystalline solid. H-Cys(tBu)-OtBu dissolves readily in common polar organic solvents such as DMF and DMSO, and is broadly compatible with a variety of coupling reagents and deprotection conditions used in modern peptide synthesis.

Product Highlights

Technical Features & Benefits

• Thiol and Carboxyl Protection: Ensures robust side-chain and alpha-carboxyl protection during peptide and oligonucleotide synthesis, preventing premature coupling and oxidation.
• Reliable Reagent for SPPS: Frequently used to incorporate protected cysteine in automated solid-phase peptide synthesis.
• Minimizes Side Reactions: Helps reduce racemization and unwanted disulfide bond formation during complex peptide assembly.
• Batch-to-Batch Consistency: Produced under stringent controls for reproducible results in synthetic workflows.
• Broad Compatibility: Easily matches with common coupling and deprotection reagents like TFA, HATU, DIC, and more.

Application Areas

• Solid-phase peptide synthesis (SPPS) of cysteine-containing peptides or proteins
• Synthesis of disulfide-bridged peptides and functional protein mimics
• Academic and industrial projects in chemical biology, medicinal chemistry, and proteomics
• Foundation for advanced peptide modifications and bioconjugation strategies

Safety & Handling

• Precautions: Wear appropriate PPE including gloves, safety goggles, and lab coat. Avoid direct contact, inhalation, or ingestion.
• Storage: Store tightly sealed in a cool, dry, dark, and inert environment. Deep freezer recommended for long-term stability.
• Disposal: Dispose of chemical waste in compliance with local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Our advanced facilities and experienced team ensure every batch is produced with extreme accuracy and high purity. Trusted industry leaders since 2013, we are known for powering pharmaceutical and peptide innovation worldwide.
• Custom Synthesis: We excel at delivering custom compounds from milligrams to multikilogram scales, tailored to precise project needs and timelines.
• Uncompromising Quality: Every product includes thorough documentation: Certificate of Analysis (COA) and comprehensive analytical data for absolute confidence in purity and identity.
• Customer-Centric Support: Our collaborative approach and responsive support keeps your research objectives our highest priority—from consultation through delivery and beyond.

Request a Quote or Sample Today!
Accelerate your peptide research and pharmaceutical innovation with SRIRAMCHEM’s quality-assured H-Cys(tBu)-OtBu. Contact our specialized team now for bulk pricing, technical support, or custom synthesis options.