Fmoc-Val-Cit-PAB-OH

Advance your targeted drug delivery, antibody–drug conjugate (ADC) synthesis, and prodrug development with Fmoc-Val-Cit-PAB-OH (CAS No.: 159858-22-7, CAT No.: SRCF-028). This specialized protected dipeptide linker features N-α-Fmoc–protected L-valine linked to citrulline and conjugated to a para-aminobenzyl (PAB) self-immolative spacer. The Val-Cit-PAB motif is widely used as a cathepsin B-cleavable linker in ADCs and prodrugs to achieve efficient enzyme-triggered drug release. The Fmoc group facilitates straightforward incorporation into solid-phase peptide synthesis (SPPS) workflows.

The compound has a molecular formula of C₃₄H₃₉N₅O₇ and a molecular weight of approximately 617.71 g/mol. It is typically supplied as a white to off-white crystalline solid with high purity (≥98%), suitable for advanced research, pharmaceutical development, and custom synthesis. It is soluble in common peptide synthesis solvents including dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP).

Product Highlights

Technical Features & Benefits

• Fmoc N-Protected Dipeptide: Facilitates straightforward incorporation into SPPS for peptide, linker, and prodrug synthesis.
• Val-Cit Linker: Known substrate for cathepsin B, enabling selective enzymatic cleavage to trigger payload release in targeted therapies.
• Para-Aminobenzyl (PAB) Spacer: Acts as a self-immolative linker that decomposes following enzymatic cleavage to release the active drug or payload moiety.
• High Purity & Batch Consistency: Manufactured under rigorous quality control to ensure reproducibility, purity, and reliable performance in pharmaceutical workflows.
• Excellent Solubility: Compatible with peptide synthesis solvents for seamless usage in automated and manual synthesis systems.
• Versatile Application: Essential for design of cathepsin B-responsive ADC linkers, prodrugs, and targeted delivery systems.

Application Areas

• Antibody–drug conjugate (ADC) synthesis with cathepsin B-cleavable linkers
• Design of enzyme-responsive prodrug and targeted drug delivery platforms
• Solid-phase peptide synthesis (SPPS) for linker, spacer, and dipeptide incorporation
• Development of bioresponsive therapeutics and peptide–drug conjugates
• Medicinal chemistry and pharmaceutical R&D focused on targeted therapies

Safety & Handling

• Wear appropriate personal protective equipment including gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and direct skin or eye contact.
• Store in a tightly sealed container in a cool, dry, ventilated area protected from light and moisture.
• Dispose of chemical waste responsibly according to all applicable local and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert synthesis and manufacturing with stringent quality control guaranteeing high purity and batch-to-batch consistency.
• Comprehensive analytical documentation including Certificate of Analysis (COA), NMR, HPLC, and LC-MS provided for every lot.
• Custom synthesis and scale-up services tailored for academic, pharmaceutical, and commercial projects.
• Responsive technical support and customer service dedicated to ensuring your project’s success.

Request a Quote or Sample Today!
Advance your antibody–drug conjugate and prodrug research with SRIRAMCHEM’s premium Fmoc-Val-Cit-PAB-OH. Contact our expert team for pricing, sample availability, or custom synthesis inquiries.