Fmoc-Val-Cit-OH

Advance your targeted drug delivery, ADC (antibody–drug conjugate) synthesis, and peptide engineering with Fmoc-Val-Cit-OH (CAS No.: 159858-21-6, CAT No.: SRCF-027). This bifunctional dipeptide consists of N-α-Fmoc–protected L-valine linked to citrulline, forming a Val-Cit sequence widely used as the cleavage site in cathepsin B–responsive linkers for ADCs and prodrugs. The Fmoc protection enables facile integration into solid-phase peptide synthesis (SPPS) workflows.

The compound has a molecular formula of C₂₈H₃₈N₄O₇ and a molecular weight of approximately 542.63 g/mol. Fmoc-Val-Cit-OH typically appears as a white to off-white crystalline powder, with high purity (≥98%) suitable for research and advanced synthesis. It is soluble in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP).

Product Highlights

Technical Features & Benefits

• Fmoc N-Protection: Enables efficient stepwise incorporation into SPPS protocols for peptide, linker, and prodrug synthesis.
• Val-Cit Cleavable Linker Segment: Recognized and cleaved by lysosomal protease cathepsin B, key to targeted drug release in ADC and prodrug design.
• High Purity & Batch Consistency: Stringently manufactured for reproducibility in conjugation and peptide modification processes.
• Solubility & Compatibility: Readily dissolves in polar aprotic solvents favored in peptide and linker chemistry.
• Versatility: Suitable for building cathepsin B–labile linker arms, targeted therapeutics, peptide-masking strategies, and bioconjugation.

Application Areas

• Antibody–drug conjugate (ADC) and prodrug linker construction
• Design of cathepsin B–cleavable peptide-based drug release systems
• Synthesis of bioresponsive linkers for targeted delivery and controlled activation
• Solid-phase peptide synthesis for research and pharmaceutical development
• Development of bioactive peptides and peptide–drug conjugates

Safety & Handling

• Wear appropriate PPE: gloves, safety glasses, and lab coat
• Avoid inhalation, ingestion, and direct contact with skin or eyes
• Store in a sealed container in a cool, dry, well-ventilated area, protected from moisture and light
• Dispose of chemical waste according to local and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert synthesis and stringent quality control assure high-purity, reliable Fmoc-Val-Cit-OH
• Lot-to-lot analytical documentation: COA, NMR, HPLC, and LC-MS provided
• Custom synthesis and contract manufacturing available for research or production scale
• Responsive technical support and proven experience in linker and peptide chemistry

Request a Quote or Sample Today!
Enhance your ADC, peptide, and targeted delivery projects with SRIRAMCHEM’s premium Fmoc-Val-Cit-OH. Contact our team for current pricing, sample availability, or custom synthesis services.