Fmoc-Tyr(tBu)-OH

Advance your peptide synthesis, medicinal chemistry, and biochemical research with Fmoc-Tyr(tBu)-OH (CAS No.: 71989-38-3, CAT No.: SRCF-025). This high-purity amino acid derivative features L-tyrosine protected at the α-amino group with a 9-fluorenylmethoxycarbonyl (Fmoc) group and the phenolic side chain protected with a tert-butyl (tBu) group. Widely used in solid-phase peptide synthesis (SPPS), the tBu group secures selective O-protection, preventing unwanted side reactions while enabling site-specific deprotection post synthesis.

The compound has a molecular formula of C₂₄H₂₅NO₅ and a molecular weight of approximately 407.46 g/mol. Fmoc-Tyr(tBu)-OH typically appears as a white to off-white crystalline powder, exhibiting high solubility in standard peptide synthesis solvents like dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), thus ensuring compatibility with both automated and manual peptide assembly workflows.

Product Highlights

Technical Features & Benefits

• Fmoc Amino Protection: Stable, base-labile group enables sequential SPPS with efficient deprotection using piperidine.
• tBu Phenol Protection: Shields the tyrosine phenolic hydroxyl functionality from side reactions during chain assembly; removable under mildly acidic conditions at the end of synthesis.
• High Purity: Manufactured under rigorous quality control to ensure reliable coupling and reproducibility.
• Excellent Solubility: Fully compatible with standard peptide synthesis solvents for automated and manual protocols.
• Versatile Building Block: Essential for synthesizing tyrosine-containing peptides, enabling investigation of phosphorylation, O-modification, and function in bioactive sequences.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) requiring tyrosine incorporation
• Assembly of peptides or proteins with site-specific tyrosine residues
• Peptide-based drug discovery, SAR, and structure-function research
• Development of probes, enzyme substrates, and functionalized biomolecules
• Protein engineering, proteomics, and modification site-selective studies

Safety & Handling

• Use appropriate PPE: gloves, lab coat, and safety glasses
• Avoid inhalation, ingestion, and skin or eye contact
• Store tightly sealed in a cool, dry, and well-ventilated area protected from light and moisture
• Dispose of chemical waste according to local, regional, and national safety regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert peptide chemistry manufacturing for high purity and batch consistency
• Comprehensive analytical documentation: COA, NMR, HPLC, and LC-MS provided with every batch
• Custom synthesis capabilities supporting mg to multi-kg scale for R&D and production
• Responsive customer and technical support to optimize your synthesis and projects

Request a Quote or Sample Today!
Advance your peptide synthesis and structure-activity studies with SRIRAMCHEM’s premium Fmoc-Tyr(tBu)-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.