Fmoc-Tyr(Me)-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-Tyr(Me)-OH (CAS No.: 77128-72-4, CAT No.: SRCF-024). This high-purity amino acid derivative features L-tyrosine methyl ether protected at the amino terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group, providing a protected aromatic residue with a methylated phenol side chain. It is an important building block for solid-phase peptide synthesis (SPPS), enabling the incorporation of modified tyrosine residues to study methylation effects and improve peptide stability and bioactivity.

The compound has the molecular formula C₁₈H₁₇NO₄ and a molecular weight of approximately 307.33 g/mol. Fmoc-Tyr(Me)-OH typically appears as a white to off-white crystalline powder and is soluble in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), facilitating efficient coupling and compatibility with automated and manual synthesis protocols.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Provides stable, base-labile protection of the amino group for seamless solid-phase peptide synthesis and easy deprotection with piperidine.
• Methylated Tyrosine Side Chain: The methyl ether modification protects the phenolic hydroxyl group, enhancing peptide stability and modulating biological activity to mimic methylated tyrosine post-translational modifications.
• High Purity & Consistency: Manufactured under rigorous quality controls ensuring reproducible coupling efficiency and batch-to-batch consistency.
• Excellent Solubility: Compatible with standard peptide synthesis solvents aiding efficient incorporation into diverse synthetic workflows.
• Versatile Building Block: Ideal for incorporation into peptides for studying protein function, signaling pathways, and structure-activity relationships of methylated tyrosine residues.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) involving methylated tyrosine residues.
• Studies on post-translational modifications and signal transduction pathways.
• Development of bioactive peptides, peptide-drug conjugates, and probes incorporating methylated tyrosine analogues.
• Medicinal chemistry research investigating peptide stability, binding, and pharmacokinetics.
• Structural biology and protein engineering involving chemically modified amino acids.

Safety & Handling

• Use appropriate personal protective equipment including gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and contact with skin or eyes.
• Store tightly sealed in a cool, dry, well-ventilated place protected from moisture, light, and heat.
• Dispose of chemical waste according to local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing and quality assurance providing ≥98% purity and high batch consistency since 2013.
• Custom synthesis and scalable supply from milligram to kilogram quantities tailored to your research needs.
• Comprehensive analytical documentation including Certificate of Analysis (COA), NMR, HPLC, and LC-MS with every batch.
• Responsive technical support and customer service to assist with synthesis, handling, and delivery.

Request a Quote or Sample Today!
Advance your peptide synthesis and medicinal chemistry projects with SRIRAMCHEM’s premium Fmoc-Tyr(Me)-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.