Fmoc-Thr(tBu)-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-Thr(tBu)-OH (CAS No.: 71989-35-0, CAT No.: SRCF-023). This high-purity amino acid derivative features L-threonine with a tert-butyl (tBu) protected side-chain hydroxyl group and a 9-fluorenylmethoxycarbonyl (Fmoc) group on the α-amino. It is a critical building block for solid-phase peptide synthesis (SPPS), enabling site-selective protection during assembly and ensuring sequence fidelity for threonine-containing peptides and bioconjugates.

The compound has a molecular formula of C₂₀H₂₅NO₅ and a molecular weight of approximately 359.42 g/mol. Typically supplied as a white to off-white crystalline powder, Fmoc-Thr(tBu)-OH exhibits excellent solubility in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), supporting smooth coupling for manual and automated peptide synthesis procedures.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Provides base-labile protection for the amino group, supporting efficient, stepwise SPPS with mild deprotection conditions.
• tBu-Protected Threonine Side Chain: Shields the β-hydroxyl group, preventing unwanted side reactions (such as O-acylation) during peptide assembly, and removed under acidic conditions after synthesis.
• High Purity & Batch Consistency: Stringently manufactured to ensure reliable coupling yields and superior peptide quality.
• Solubility: Fully compatible with polar aprotic solvents used for modern peptide synthesis workflows.
• Versatile Application: Ideal for preparation of site-specifically protected threonine peptides, complex polypeptides, and bioconjugates for research and pharmaceutical development.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) requiring threonine incorporation
• Custom synthesis of peptides for phosphorylation, glycosylation, and O-linked modifications
• Medicinal chemistry and SAR studies of threonine-rich peptides
• Preparation of peptide-based therapeutics, enzyme substrates, and protein analogues
• Chemical biology, proteomics, and structure-function research

Safety & Handling

• Use appropriate PPE: gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and direct contact with skin or eyes.
• Store tightly sealed in a cool, dry, well-ventilated place, protected from moisture and light.
• Dispose of waste in compliance with local, regional, and national chemical safety regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Stringent manufacturing ensures high purity and batch-to-batch consistency since 2013.
• Comprehensive analytical documentation: Certificate of Analysis (COA), NMR, HPLC, and LC-MS provided with every batch.
• Flexible supply capabilities for research to industrial scales, with reliable technical support.
• Dedicated customer service and peptide chemistry consultation for custom synthesis and projects.

Request a Quote or Sample Today!
Accelerate your peptide synthesis with SRIRAMCHEM’s premium Fmoc-Thr(tBu)-OH. Contact our expert team for pricing, sample availability, or custom synthesis solutions tailored to your project.