Fmoc-Ser-OH

Advance your peptide synthesis, biochemical research, and medicinal chemistry with Fmoc-Ser-OH (CAS No.: 73724-45-5, CAT No.: SRCF-022). This high-purity amino acid derivative features L-serine protected at the amino terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group, making it an essential building block for solid-phase peptide synthesis (SPPS), phosphorylation site studies, and preparation of serine-rich peptides or protein analogues.

The compound has a molecular formula of C₁₆H₁₅NO₅ and a molecular weight of approximately 301.30 g/mol. Fmoc-Ser-OH typically appears as a white to off-white crystalline powder and is soluble in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), ensuring efficient coupling and compatibility with both automated and manual synthesis workflows.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Provides base-labile protection of the amino group, allowing standard SPPS and facile deprotection with piperidine.
• Serine Residue: Contains a hydroxymethyl (-CH₂OH) side chain for O-linked modifications, phosphorylation studies, and enhanced hydrogen bonding in peptides.
• High Purity & Consistency: Rigorous quality control ensures reliable batch-to-batch performance and excellent coupling efficiency.
• Versatile Solvent Compatibility: Soluble in peptide-relevant polar aprotic solvents for robust integration into modern synthesis workflows.
• Fundamental Building Block: Used in chemical biology, proteomics, and synthesis of therapeutic peptides and glycopeptides.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) of serine-rich sequences
• Construction of peptides for phosphorylation and enzyme substrate studies
• Preparation of glycopeptides, mimetics, and protein analogues
• Biochemical research and structure-activity relationship (SAR) studies
• Development of peptide-based therapeutics and probes

Safety & Handling

• Use appropriate PPE: gloves, lab coat, and safety goggles
• Avoid inhalation, ingestion, and contact with skin or eyes
• Store sealed in a cool, dry, well-ventilated area, protected from moisture and light
• Dispose of chemical waste in accordance with local and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Stringent manufacturing with guaranteed purity and batch consistency
• Reliable supply and custom synthesis from mg to kg scale
• Full analytical documentation: Certificate of Analysis (COA), NMR, HPLC, LC-MS for every batch
• Responsive technical advice and customer support through the entire project lifecycle

Request a Quote or Sample Today!
Enhance your peptide chemistry and synthetic research with SRIRAMCHEM’s premium Fmoc-Ser-OH. Contact our expert team now for pricing, availability, or custom synthesis needs.