Fmoc-Leu-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-Leu-OH (CAS No.: 35661-60-0, CAT No.: SRCF-015). This high-purity amino acid derivative features L-leucine protected at the amino terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group, making it an essential building block for solid-phase peptide synthesis (SPPS), peptide modification, and structure-activity relationship studies involving leucine residues.

The compound has a molecular formula of C₁₅H₂₁NO₄ and a molecular weight of approximately 263.33 g/mol. Fmoc-Leu-OH typically appears as a white to off-white crystalline powder and is soluble in common organic solvents like dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), facilitating efficient coupling reactions and synthetic flexibility.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Provides stable, base-labile protection of the amino group, ideal for efficient stepwise solid-phase peptide synthesis and easy deprotection with piperidine.
• L-Leucine Residue: A hydrophobic, branched-chain amino acid important for protein folding, hydrophobic interactions, and bioactivity.
• High Purity & Batch Consistency: Manufactured under strict quality control to ensure reproducibility, high coupling efficiency, and reliability in research.
• Excellent Solubility: Compatible with standard peptide synthesis solvents to facilitate smooth coupling reactions and synthetic workflows.
• Versatile Intermediate: Widely used for peptide elongation, medicinal chemistry, and development of bioactive peptides and analogues.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS)
• Preparation of peptides containing leucine residues for structural and functional studies
• Medicinal chemistry and drug discovery involving hydrophobic peptide segments
• Development of peptide-based ligands, agonists, antagonists, and therapeutics
• Research in enzyme modulation, protein-protein interactions, and SAR studies

Safety & Handling

• Use appropriate personal protective equipment such as gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and contact with skin or eyes.
• Store tightly sealed in a cool, dry, well-ventilated place away from moisture, heat, and light.
• Dispose of chemical waste in compliance with local, regional, and national safety regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing facilities ensuring high purity and batch-to-batch consistency since 2013.
• Custom synthesis and scale-up capabilities tailored to your research needs, from milligram to multi-kilogram quantities.
• Comprehensive documentation including Certificate of Analysis (COA), NMR, HPLC, and LC-MS data provided with every batch.
• Responsive technical support and customer service throughout your research and development process.

Request a Quote or Sample Today!
Accelerate your peptide synthesis and medicinal chemistry programs with SRIRAMCHEM’s premium Fmoc-Leu-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.