Fmoc-His(Trt)-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-His(Trt)-OH (CAS No.: 109425-51-6, CAT No.: SRCF-020). This protected amino acid derivative features L-histidine with a trityl (Trt) group safeguarding the imidazole side chain, and a 9-fluorenylmethoxycarbonyl (Fmoc) group at the α-amino terminus. It is a critical building block for solid-phase peptide synthesis (SPPS), enabling selective protection of histidine residues to prevent side reactions and ensuring high structural fidelity during peptide assembly.

The compound has a molecular formula of C₃₄H₃₁N₃O₄ and a molecular weight of approximately 553.63 g/mol. Typically supplied as a white to off-white crystalline powder, Fmoc-His(Trt)-OH exhibits excellent solubility in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), facilitating efficient coupling in both manual and automated peptide synthesis workflows.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Provides base-labile protection of the amino group, facilitating stepwise peptide assembly with facile deprotection by piperidine.
• Trityl (Trt) Side Chain Protection: Safeguards the reactive imidazole side chain of histidine, preventing undesired side reactions during peptide synthesis.
• High Purity & Batch Consistency: Manufactured with strict quality control to ensure reproducible coupling efficiency and peptide integrity.
• Excellent Solubility: Compatible with common peptide synthesis solvents, ensuring smooth incorporation into manual and automated synthetic protocols.
• Versatile Intermediate: Essential for synthesizing histidine-containing peptides, analogs, and bioconjugates with selective protection.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) involving histidine residues.
• Medicinal chemistry and drug discovery projects requiring peptides with protected imidazole side chains.
• Preparation of targeted histidine-containing bioactive peptides and protein analogues.
• Design of peptide-based inhibitors, molecular probes, and enzyme substrates.
• Studies in protein engineering, peptide therapeutics, and structure-function relationships.

Safety & Handling

• Use appropriate personal protective equipment including gloves, lab coat, and safety goggles.
• Avoid inhalation, ingestion, and skin or eye contact.
• Store tightly sealed in a cool, dry, well-ventilated area protected from moisture and direct light.
• Dispose of chemical waste in accordance with local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with rigorous quality control ensuring high purity and batch-to-batch consistency.
• Comprehensive documentation including Certificate of Analysis (COA), NMR, HPLC, and LC-MS provided with every batch.
• Custom synthesis capabilities and scale-up services tailored to your research and manufacturing needs.
• Responsive technical support and customer service throughout your R&D lifecycle.

Request a Quote or Sample Today!
Enhance your peptide synthesis and medicinal chemistry research with SRIRAMCHEM’s premium Fmoc-His(Trt)-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.