Fmoc-Asn(Trt)-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-Asn(Trt)-OH (CAS No.: 132388-59-1, CAT No.: SRCF-034). This protected amino acid derivative features L-asparagine with a trityl (Trt) group protecting the side-chain amide, and a 9-fluorenylmethoxycarbonyl (Fmoc) group at the α-amino terminus. It is an essential building block for solid-phase peptide synthesis (SPPS), preventing side reactions involving the asparagine side chain and ensuring sequence fidelity during peptide assembly.

The compound has a molecular formula of C₂₇H₂₈N₂O₅ and a molecular weight of approximately 456.52 g/mol. Typically supplied as a white to off-white crystalline powder, Fmoc-Asn(Trt)-OH exhibits excellent solubility in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), enabling efficient coupling in automated and manual peptide synthesis workflows.

Product Highlights

Technical Features & Benefits

• Dual Protection: Fmoc protects the α-amino group with a base-labile group suitable for stepwise SPPS, while the Trt group safeguards the side-chain amide of asparagine, preventing side reactions during peptide assembly.
• High Purity & Consistency: Manufactured under stringent quality control to ensure reproducible coupling efficiency and peptide integrity.
• Excellent Solubility: Compatible with commonly used solvents in peptide synthesis enabling seamless integration into automated and manual protocols.
• Versatile Building Block: Widely used in peptide synthesis, medicinal chemistry, and research requiring site-specific Asn incorporation with side-chain protection.
• Stable Crystalline Powder: Facilitates accurate weighing, handling, and long-term storage stability.

Application Areas

• Solid-phase and solution-phase peptide synthesis incorporating Asn residues.
• Construction of peptides and proteins requiring selective side-chain protection of asparagine.
• Medicinal chemistry and pharmaceutical research involving bioactive peptides.
• Design of peptide-based therapeutics, probes, and protein analogues.
• Research in protein engineering, structure-activity relationships, and peptide modifications.

Safety & Handling

• Use appropriate personal protective equipment including gloves, lab coat, and safety goggles.
• Avoid inhalation, ingestion, and contact with skin or eyes.
• Store tightly sealed in a cool, dry, well-ventilated place away from moisture and direct light.
• Dispose of chemical waste according to local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with rigorous quality control ensuring high purity and reproducibility since 2013.
• Reliable supply of research-grade Fmoc-Asn(Trt)-OH with comprehensive analytical documentation including COA, NMR, HPLC, and LC-MS.
• Custom synthesis and scale-up services tailored to your peptide synthesis and pharmaceutical development requirements.
• Responsive technical support and dedicated customer service to assist throughout your research lifecycle.

Request a Quote or Sample Today!
Advance your peptide synthesis and medicinal chemistry projects with SRIRAMCHEM’s premium Fmoc-Asn(Trt)-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.