Fmoc-Arg(Pbf)-OH

Advance your peptide synthesis, medicinal chemistry, and bioconjugation projects with Fmoc-Arg(Pbf)-OH (CAS No.: 154445-77-9, CAT No.: SRCF-032). This high-purity amino acid derivative features L-arginine protected at the α-amino group with a 9-fluorenylmethoxycarbonyl (Fmoc) group and the guanidino side chain protected with a 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) group. Fmoc-Arg(Pbf)-OH is an indispensable building block for solid-phase peptide synthesis (SPPS), providing selective protection to minimize side reactions, prevent arginine aggregation, and ensure sequence fidelity.

The compound has a molecular formula of C₃₈H₄₆N₄O₈S and a molecular weight of approximately 734.87 g/mol. It is typically offered as a white to off-white crystalline powder, exhibiting high solubility in standard peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP) to ensure maximum coupling efficiency and compatibility with automated and manual peptide assembly workflows.

Product Highlights

Technical Features & Benefits

• Fmoc & Pbf Dual Protection: Fmoc provides standard base-labile protection for stepwise SPPS; Pbf robustly shields arginine’s guanidino group, preventing side reactions and facilitating clean, high-yield deprotection under acidic conditions.
• High Chemical Purity: Ensures reproducible coupling, minimized aggregation, and reliable peptide synthesis outcomes.
• Excellent Solubility: Compatible with all modern peptide synthesis solvents for fully automated or manual workflows.
• Versatile Building Block: Essential for peptides requiring arginine-rich sequences, cell-penetrating peptides, biomolecule conjugates, and pharmaceutical research.
• Stable & Easy to Handle: Offered as a crystalline powder for accurate weighing, long shelf life, and hassle-free storage.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) involving arginine residues
• Preparation of bioactive peptides—including cell-penetrating, antimicrobial, and signaling peptides
• Medicinal chemistry for drug development, enzyme substrate design, and pharmacological candidate synthesis
• Investigations of protein–protein and protein–nucleic acid interactions involving basic peptide moieties
• Design of bioconjugates, glycopeptides, and modified proteins

Safety & Handling

• Use appropriate personal protective equipment (gloves, lab coat, goggles)
• Avoid inhalation, ingestion, and direct contact with skin or eyes
• Store tightly sealed in a cool, dry, well-ventilated area, protected from light and moisture
• Dispose of chemical waste in accordance with all local, regional, and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with rigorous quality control for ≥98% purity and batch consistency
• Comprehensive analytical documentation (COA, NMR, HPLC, LC-MS) provided for every batch
• Custom synthesis services available, from mg to multi-kg scale
• Responsive technical support and customer service to assist your research at every stage

Request a Quote or Sample Today!
Facilitate your peptide and biomedical projects with SRIRAMCHEM’s premium Fmoc-Arg(Pbf)-OH. Contact our expert team for pricing, sample requests, or custom synthesis inquiries.