Fmoc-3-iodo-L-Alanine methyl ester

Advance your peptide synthesis, medicinal chemistry, and bio-conjugation research with Fmoc-3-iodo-L-Alanine methyl ester (CAS No.: 156017-42-4, CAT No.: SRCF-006). This compound features the L-isomer of 3-iodoalanine esterified as a methyl ester and protected at the N-terminus with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. The unique iodine functionality enables selective post-synthetic modification (e.g., cross-coupling, radio-labeling) and is highly valuable in solid-phase peptide synthesis (SPPS), incorporation of non-canonical amino acids, and advanced peptide modification strategies.

The molecular formula is C₁₈H₁₈INO₄ and the molecular weight is approximately 439.25 g/mol. Fmoc-3-iodo-L-Alanine methyl ester typically appears as a white to off-white crystalline solid, demonstrating high purity and solubility in common peptide synthesis solvents such as DMF, DMSO, and NMP—facilitating reliable incorporation in both manual and automated peptide assembly workflows.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Enables standard base-labile N-terminal protection for seamless incorporation into SPPS protocols.
• 3-Iodo Substitution: Unique electrophilic handle allows post-synthetic cross-coupling (e.g., Suzuki, Sonogashira) and functional diversification.
• L-Alanine Stereochemistry: Preserves biological relevance with optical purity for peptide/biopolymer synthesis.
• Methyl Ester C-Terminus: Provides C-protection for downstream derivatization or ester hydrolysis if required.
• High Purity & Stability: Manufactured under strict controls for consistent performance in peptide synthesis.

Application Areas

• Incorporation as a building block in solid-phase peptide synthesis (SPPS)
• Introduction of iodine as a site-specific modification for radiolabeling or cross-coupling
• Peptide-based drug design and non-canonical amino acid incorporation
• Medicinal chemistry and chemical biology probe development
• Research on structure-activity relationships (SAR) of modified peptides

Safety & Handling

• Use appropriate PPE: gloves, goggles, and lab coat
• Avoid inhalation, ingestion, and skin/eye contact
• Store tightly sealed in a cool, dry, well-ventilated area, away from moisture and light
• Dispose of chemical waste as per local and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing and stringent quality control for high-purity, research-grade compounds
• Custom synthesis and scale-up available (mg–kg), tailored to your research needs
• Comprehensive analytical documentation (COA, NMR, HPLC, LC-MS) with every batch
• Dedicated technical support and consultation from order through delivery

Request a Quote or Sample Today!
Enhance your peptide chemistry and medicinal research with SRIRAMCHEM’s premium Fmoc-3-iodo-L-Alanine methyl ester. Contact our expert team for competitive pricing, sample availability, or to discuss your custom synthesis requirements.