Boc-Val-Cit-PAB-OH

Drive next-generation biomedical research and targeted therapeutics with Boc-Val-Cit-PAB-OH (CAS No.: 870487-09-5, CAT No.: SRCB-040), a high-purity, multifunctional linker used extensively in antibody-drug conjugate (ADC) technology. This tri-segment peptide-based molecule—containing N^α-Boc protected valine, citrulline, and a self-immolative p-aminobenzyl (PAB) spacer terminated as a carboxylic acid—enables engineered drug delivery systems in oncological therapy and bioanalytical development.

The molecular formula is C₂₉H₄₀N₆O₇ and the molecular weight is 588.67 g/mol. Boc-Val-Cit-PAB-OH typically appears as a white to off-white powder, is highly pure (≥98%), and shows excellent solubility in DMSO, DMF, and most polar organics. This linker is designed for enzymatic cleavability by cathepsin B or related proteases in lysosomes, followed by spontaneous PAB elimination, enabling controlled release of payloads such as cytotoxics or fluorescent markers.

Product Highlights

Technical Features & Benefits

• Cathepsin B/Lysosomal Cleavable Linker: Enables controlled payload release in ADC and targeted drug conjugate systems after enzymatic processing in tumor cells.

• Boc-Protected for Versatile Synthesis: The N^α-Boc group allows stepwise solid- or solution-phase conjugation and stability in multi-step processes.

• Self-Immolative PAB Spacer: Facilitates traceless drug (payload) release by spontaneous self-elimination after enzymatic cleavage.

• High Purity Synthetic Grade: Batch-verified (≥98%) and suitable for regulated research, preclinical, and development environments.

• Optimal Solubility: Ready for use in organic media for peptide synthesis, conjugations, and payload attachment.

Application Areas

• Antibody-drug conjugate (ADC) linker-payload design for targeted cancer therapies

• Synthesis of enzyme-cleavable and self-immolative prodrugs

• Bioanalytical and diagnostic probe development

• Research tool for investigating lysosomal delivery and proteolytic activation

• Innovative model for bioconjugation and drug delivery system studies

Safety & Handling

• Handling Precautions: Work with standard laboratory PPE (gloves, goggles, lab coat) in a fume hood. Avoid ingestion, inhalation, and direct skin or eye contact.

• Storage Recommendations: Store tightly closed at −20°C, desiccated, and protected from light for long-term stability. Warm to room temperature before opening.

• Disposal: Dispose of in accordance with local, regional, and national regulations as hazardous organic chemical waste.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Precision synthesis and full analytical support ensure high purity, batch reproducibility, and quality for regulated R&D projects.
• Custom Synthesis: Scalable from milligram to kilogram, with technical support for special linkers and payload conjugates.
• Comprehensive Quality Documentation: Certificate of Analysis (COA), HPLC, NMR, and MS data provided for every lot.
• Responsive Project Support: Fast, expert service from initial quote to delivery and technical aftercare.

Request a Quote or Sample Today!
Empower your ADC, diagnostic, or targeted delivery pipeline with premium-grade Boc-Val-Cit-PAB-OH from SRIRAMCHEM. Contact our team to discuss technical specifications, pricing, or custom linker requirements for your next breakthrough.