Boc-Pro-OH

Streamline your peptide synthesis and biomedical research with Boc-Pro-OH (CAS No.: 15761-39-4, CAT No.: SRCB-054), a high-purity N-tert-butoxycarbonyl protected L-proline derivative. This protected amino acid features a Boc group on the α-amino terminus, preserving the secondary amine of proline for selective and efficient incorporation into peptide chains. Boc-Pro-OH is a vital building block in both solid-phase and solution-phase peptide assembly, utilized for its rigid five-membered pyrrolidine ring that imparts conformational control and structural rigidity to peptides and proteins. Its molecular formula is C₁₀H₁₇NO₄ with a molecular weight of 215.25 g/mol. Boc-Pro-OH is typically supplied as a white to off-white crystalline powder, offering high purity (≥98%) and excellent solubility in DMF, DCM, and methanol.

Product Highlights

Technical Features & Benefits

• Boc-Protected Proline: Facilitates orthogonal protection and compatibility with both solid-phase and solution-phase peptide synthesis protocols.

• Cyclic Secondary Amine: Proline’s rigid pyrrolidine ring imparts structural constraints useful for peptide folding and secondary structure studies.

• High Purity & Reproducibility: ≥98% purity ensures reliable performance in chemical, pharmaceutical, and biochemical research applications.

• Good Organic Solubility: Easy dissolution in modern peptide synthesis solvents streamlines workflow and scalability.

• Efficient Boc Removal: Boc group can be smoothly removed under mild acidic conditions for seamless peptide engineering or elongation.

Application Areas

• Solid-phase and solution-phase peptide synthesis for proline-containing sequences

• Structural and folding studies of peptides and proteins (influences on helices and turns)

• Synthesis of peptidomimetics and building blocks for medicinal chemistry

• Preparation of enzyme inhibitors, bioconjugates, and specialty biomaterials

Safety & Handling

• Handling Precautions: Use appropriate PPE including gloves, goggles, and lab coat. Avoid inhalation, ingestion, and contact with skin or eyes.

• Storage Recommendations: Store in a tightly closed container in a cool, dry, and well-ventilated place, protected from light and humidity.

• Disposal: Dispose of unused material according to local, regional, or national environmental regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: High-purity synthesis and advanced QC for assured lot-to-lot consistency, backed by full analytical documentation (COA, NMR, HPLC, MS).
• Custom Synthesis: Flexible scales, specification matching, and custom derivatives for research or commercial supply.
• Comprehensive Quality Support: Analytical data provided with each lot for traceability, regulatory compliance, and reliable R&D outcomes.
• Responsive Service: Technical and commercial support for fast turnaround, from inquiry to delivery and post-sale consultation.

Request a Quote or Sample Today!
Accelerate your peptide synthesis and discovery with SRIRAMCHEM’s high-quality Boc-Pro-OH. Contact us for pricing, technical queries, or custom synthesis requirements.