Boc-Lys(Fmoc)-OH

Drive advanced peptide synthesis and biomedical research with Boc-Lys(Fmoc)-OH (CAS No.: 84624-27-1, CAT No.: SRCB-063), a dual-protected L-lysine derivative featuring an N^α-tert-butoxycarbonyl (Boc) group on the α-amino terminus and an N^ε-fluorenylmethyloxycarbonyl (Fmoc) group on the ε-amino side chain. This orthogonally protected amino acid is a critical building block for modern stepwise solid-phase and solution-phase peptide assembly, enabling highly selective, stepwise incorporations and branched or modified peptide designs. Boc-Lys(Fmoc)-OH offers exceptional control in combinatorial chemistry, peptide mapping, and bioconjugation projects, allowing site-specific manipulation of the lysine ε-amino group following deprotection.

Its molecular formula is C₂₇H₃₄N₂O₆ with a molecular weight of 482.57 g/mol. Typically supplied as a white to off-white crystalline powder, this product demonstrates outstanding purity (≥98%) and solubility in standard peptide synthesis solvents (DMF, DCM, methanol).

Product Highlights

Technical Features & Benefits

• Orthogonal Dual Protection: Boc and Fmoc groups enable independent deprotection of the α- and ε-amino groups, facilitating complex peptide and protein architectures.
• High Purity & Batch Consistency: Ensures reliable results during highly demanding peptide synthesis, especially in combinatorial and branched peptide projects.
• Versatile Synthetic Utility: Ideal for synthesizing mono- or multi-functionalized peptides, bioconjugation, and advanced ligand development.
• Efficient Solubility Profile: Ready for use in all major organic solvents supporting modern peptide synthesis protocols.
• Easy Boc/Fmoc Removal: Boc removed with acid (TFA), Fmoc cleaved selectively under mild base (piperidine), allowing for strategic sequence modifications.

Application Areas

• Stepwise solid-phase and solution-phase peptide synthesis requiring orthogonally protected lysine
• Synthesis of branched peptides, side-chain modification, or functionalization
• Preparation of polyfunctional bioconjugates, probes, and custom peptides
• Protein labeling, combinatorial libraries, and SAR studies

Safety & Handling

• Handling Precautions: Use gloves, lab coat, and safety goggles. Avoid inhalation, ingestion, and contact with skin or eyes.
• Storage Recommendations: Store tightly closed in a cool, dry, well-ventilated location, protected from light and humidity.
• Disposal: Dispose according to local, regional, and national chemical regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Advanced synthesis and stringent quality control for batch-to-batch consistency and high purity.
• Custom Synthesis: Flexible order sizes, tailored modifications, and analytical support for specialized research needs.
• Comprehensive Quality Documentation: COA, NMR, HPLC, and MS data supporting every batch for full traceability and confidence.
• Responsive Customer Support: Dedicated technical advisors for seamless order management and troubleshooting.

Request a Quote or Sample Today!
Accelerate your peptide innovation and biomedical research with SRIRAMCHEM’s premium Boc-Lys(Fmoc)-OH. Contact our team for pricing, technical information, or custom synthesis services to empower your next breakthrough.