Boc-His-OH

Empower your peptide synthesis and biochemical research with Boc-His-OH (CAS No.: 17791-52-5, CAT No.: SRCB-062), a high-purity N-tert-butoxycarbonyl protected L-histidine derivative. This protected amino acid features a Boc group on the α-amino terminus and a free imidazole side chain, making it a foundational building block for both solid-phase and solution-phase peptide assembly.

Boc-His-OH facilitates selective coupling of histidine residues in peptides, minimizing racemization and side reactions. The imidazole side chain retains its functional activity for coordination chemistry, enzymatic roles, and molecular recognition. The molecular formula is C₁₁H₁₇N₃O₄ with a molecular weight of 255.27 g/mol. Typically supplied as a white to off-white crystalline powder, Boc-His-OH is highly pure (≥98%) and offers excellent solubility in DMF, DCM, methanol, and similar peptide synthesis solvents.

Product Highlights

Technical Features & Benefits

• Boc-Protected Histidine: Shields the amine terminus for stepwise and selective peptide coupling, preserving imidazole reactivity and stereochemistry.

• High Purity & Batch Consistency: ≥98% purity ensures reproducibility for pharmaceutical and biochemical research.

• Free Imidazole Side Chain: Allows coordination chemistry, hydrogen bonding, catalysis, and protein engineering applications.

• Excellent Organic Solubility: Compatible with all standard peptide synthesis protocols and reagents.

• Mild Deprotection Conditions: Boc group is removable under mild acid (e.g., TFA) without harming the imidazole ring or peptide backbone.

Application Areas

• Solid-phase and solution-phase peptide synthesis for histidine-containing sequences

• Preparation of peptide drugs, peptidomimetics, and enzyme substrates

• Protein engineering and structure-activity studies involving imidazole functional groups

• Biochemical research requiring selective histidine modification or labeling

Safety & Handling

• Handling Precautions: Use gloves, lab coat, safety glasses; avoid inhalation, ingestion, and contact with skin or eyes.

• Storage Recommendations: Store tightly closed in a cool, dry, well-ventilated area, protected from light and humidity.

• Disposal: Dispose of chemical waste in compliance with local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Advanced synthesis and rigorous quality control supporting high-purity production and batch-to-batch reproducibility.
• Custom Synthesis: Flexible scale options and modification support for peptide R&D and manufacturing.
• Comprehensive Analytical Support: COA, NMR, HPLC, and MS documentation included with each shipment.
• Responsive Customer Support: Prompt, knowledgeable technical and sales help at every step, from inquiry to delivery.

Request a Quote or Sample Today!
Enhance your peptide synthesis and research pipeline with SRIRAMCHEM’s premium Boc-His-OH. Contact us for pricing, availability, or custom synthesis support tailored to your project needs.