Boc-Cys(Acm)-OH

Streamline your peptide synthesis and advanced biochemical research with Boc-Cys(Acm)-OH (CAS No.: 19746-37-3, CAT No.: SRCB-056), a high-purity N-tert-butoxycarbonyl protected L-cysteine derivative featuring an S-acetamidomethyl (Acm) group on the thiol side chain. This orthogonally protected amino acid is a premier building block for solid-phase and solution-phase peptide synthesis when selective protection of the cysteine thiol is required, especially for constructing peptides with multiple disulfide bridges or for late-stage disulfide bond formation/masking.

The molecular formula is C₁₂H₁₈N₂O₅S and the molecular weight is 302.35 g/mol. Boc-Cys(Acm)-OH is typically supplied as a white to off-white crystalline powder, with excellent purity (≥98%) and good solubility in DMF, DCM, and methanol. The Acm group offers robust protection through standard coupling, is stable to acids, and can be selectively removed with mild oxidative conditions (e.g., iodine treatment), leaving the Boc group and other sensitive residues intact.

Product Highlights

Technical Features & Benefits

• Boc and Acm Dual Protection: Boc group ensures amine protection for selective coupling; Acm group protects cysteine’s thiol, enabling orthogonal deprotection strategies for disulfide bond formation.

• High Purity & Batch Consistency: Suitable for demanding research, peptide synthesis, and GMP environments where sequence and protection fidelity are critical.

• Selective Deprotection: Acm group removable with iodine or silver ion oxidation, leaving other sensitive side chains intact; Boc removable under mild acid.

• Excellent Solubility: Compatible with standard peptide coupling reagents and solvents.

• Solid-Phase & Solution-Phase Synthesis Ready: Critical intermediate for constructing complex peptides with multiple cysteines and controlled folding patterns.

Application Areas

• Solid-phase and solution-phase peptide synthesis, especially for peptides with more than one cysteine or planned sequential disulfide formation

• Synthesis of disulfide-rich peptides, miniproteins, and therapeutic analogues

• Orthogonal protection schemes in peptide drugs and bioactive molecule development

• Bioconjugation requiring selective thiol manipulation

Safety & Handling

• Handling Precautions: Use appropriate laboratory PPE, including gloves, safety goggles, and lab coat. Avoid inhalation, ingestion, and skin or eye contact.

• Storage Recommendations: Store tightly closed in a cool, dry, well-ventilated area, protected from light and moisture.

• Disposal: Dispose of in accordance with your institution’s hazardous waste protocols.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Stringent purity controls and advanced synthetic routes tailored for peptide research and production.
• Custom Synthesis: Scalable from milligram to multi-kilogram, with support for tailored protection/deprotection strategies.
• Comprehensive Documentation: Full COA, NMR, HPLC, and MS supplied for every lot.
• Responsive Client Service: Dedicated technical and commercial support from inquiry through delivery.

Request a Quote or Sample Today!
Boost your peptide synthesis and complex biomolecule research with SRIRAMCHEM’s high-quality Boc-Cys(Acm)-OH. Contact our team for pricing, samples, or custom synthesis solutions.