4-Methoxy-2-nitroaniline

Advance your proton pump inhibitor and antimalarial synthesis with 4-methoxy-2-nitroaniline (CAS No.: 96-96-8, CAT No.: SRCM-031). This ortho-nitro para-methoxy aniline serves as a key intermediate in omeprazole sodium production and primaquine phosphate manufacturing, enabling selective nitro-reduction and diazotization in multi-step API routes.

With a molecular formula of C₇H₈N₂O₃ and a molecular weight of 168.15 g/mol, it appears as an orange to red crystalline powder with a melting point of 123-127°C. Slightly soluble in water but readily soluble in polar organic solvents, its electron-rich aromatic system supports clean SNAr and diazo coupling chemistry.

Product Highlights

Technical Features & Benefits

• • Omeprazole Key Intermediate: Starting material for proton pump inhibitor synthesis via selective nitro-reduction to 2,3-diamino-4-methoxyanisole.

• • Primaquine Precursor: Enables antimalarial synthesis through diazotization and Sandmeyer reaction sequences.

• • Ortho-Director Control: Nitro group directs selective ortho-functionalization while methoxy activates para position for coupling.

• • High Thermal Stability: Sharp melting range (123?127?C) supports robust purification and scale-up processes.

• • Dye Intermediate Quality: ?98% GC purity suitable for both pharmaceutical and pigment applications.

Application Areas

• • Key raw material for omeprazole sodium and related proton pump inhibitors.

• • Intermediate in primaquine phosphate antimalarial drug synthesis.

• • Diazo component (Fast Bordeaux GP Base) for azo pigment and dye manufacturing.

• • Building block for substituted benzimidazoles and nitroaniline derivatives.

• • Research reagent in molluscicidal and hemolytic anemia studies.

Safety & Handling

• • Fatal if swallowed, inhaled, or skin contact; wear full PPE including respirator.

• • Causes skin/eye irritation; handle only in chemical fume hood with adequate ventilation.

• • Store locked up in cool (<15°C), dark, well-ventilated place; UN2811 toxic solid.

• • Immediate medical attention required for exposure; dispose as hazardous waste.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Proven expertise in nitroaniline intermediates for PPI and antimalarial APIs.

• • Custom synthesis scale-up from research to commercial quantities.

• • Complete analytical package: COA, NMR, GC/HPLC, LC-MS for regulatory compliance.
• Technical support for diazotization optimization, nitro-reduction, and pigment coupling.

Request a Quote or Sample Today! Power your omeprazole, primaquine, and azo dye production with SRIRAMCHEM’s premium 4-methoxy-2-nitroaniline. Contact the expert team for pricing, availability, or custom synthesis support.