4-Methoxy-1,2-phenylenediamine

Power your proton pump inhibitor manufacturing with 4-methoxy-1,2-phenylenediamine (CAS No.: 59548-39-9, CAT No.: SRCM-032). This critical o-phenylenediamine derivative serves as the penultimate intermediate in omeprazole synthesis, enabling cyclization with 2-chloromethyl-3,5-dimethyl-4-methoxypyridine to form the benzimidazole core of this blockbuster PPI.

With a molecular formula of C₇H₁₀N₂O and a molecular weight of 138.17 g/mol, it appears as a white to amber powder or low-melting solid (48?52 ?C free base). Soluble in DMSO and polar solvents, its vicinal diamine functionality supports clean condensation chemistry under acidic conditions typical of industrial omeprazole processes.

Product Highlights

Technical Features & Benefits

• • Omeprazole Penultimate Intermediate: Direct precursor via nitro-reduction of 4-methoxy-2-nitroaniline; condenses with chloromethylpyridine to form PPI core.

• • Vicinal Diamine Reactivity: Ortho-amino groups enable regioselective benzimidazole formation under acidic catalysis.

• • Process-Stable Free Base: Low melting point (48-52°C) facilitates handling; available as stable dihydrochloride salt.

• • High Purity for GMP: ?98% GC purity supports commercial-scale omeprazole campaigns and impurity profiling.

• • Scalable Nitro-Reduction: Clean conversion from nitroaniline precursor using standard hydrogenation or metal/acid systems.

Application Areas

• • Key intermediate in omeprazole, esomeprazole, and proton pump inhibitor manufacturing.

• • Building block for substituted benzimidazoles, antioxidants, and polymer cross-linkers.

• • Reference standard for omeprazole process validation and impurity control.

• • Starting material for custom benzimidazole libraries and SAR studies.

• • Synthetic reagent in heterocyclic methodology development.

Safety & Handling

• • Toxic if swallowed/inhaled; strong skin/eye irritant?wear full PPE including respirator.

• • Handle in fume hood; potential sensitizer and mutagenic concerns require strict containment.

• • Store under nitrogen at 2?8?C in amber containers; light- and air-sensitive.

• Dispose as hazardous chemical waste per pharmaceutical regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Industrial expertise in PPI intermediates with proven omeprazole supply chain reliability.

• • Custom synthesis from nitroaniline through benzimidazole; gram-to-tonne scale-up.

• • Full GMP analytical package: COA, NMR, HPLC, LC-MS compliant with pharmacopoeial standards.

• Technical partnership for process optimization, impurity qualification, and technology transfer.

Request a Quote or Sample Today! Secure your omeprazole production pipeline with SRIRAMCHEM’s premium 4-methoxy-1,2-phenylenediamine. Contact the expert team for pricing, availability, or custom PPI intermediate requirements.