3-(2-Iodoacetamido)-Propyl

Enhance your biochemical, pharmaceutical, and analytical research with 3-(2-Iodoacetamido)-Propyl (CAT No.: SRCI-003). This compound, commonly encountered as its PROXYL derivative or as a related spin label, features an iodoacetamido group attached to a propyl chain, making it a powerful and selective reagent for covalent modification of sulfhydryl (–SH) groups on proteins, peptides, and other biomolecules. The iodoacetamido functionality acts as an alkylating agent, enabling the formation of stable thioether bonds with cysteine residues—making it an excellent probe for site-selective protein labeling, spin labeling for EPR spectroscopy, and bioconjugation studies. The compound can also serve as a versatile intermediate for the synthesis of broader classes of bioactive molecules and is highly useful for mapping protein structure, exploring enzyme mechanism, and facilitating advanced peptide modification strategies.

Typical analogs (e.g., 3-(2-Iodoacetamido)-PROXYL) possess a molecular formula of C₁₀H₁₈IN₂O₂ and molecular weight of approximately 325.17 g/mol. Physical properties include a yellow to very dark orange solid, melting point of 162–164°C, and slight solubility in DMSO, methanol, and chloroform. Stable at 2–8°C, but light and heat-sensitive—store refrigerated and protected from light. The compound is ≥98% purity, suitable for advanced research and industrial applications.

Product Highlights

Technical Features & Benefits

• Selective Alkylating Agent: Targets thiol groups on biomolecules for robust covalent modification.
• Spin Label/Reagent: Enables EPR/ESR spectroscopy studies of protein and membrane dynamics.
• Stable Free Radical: As a PROXYL derivative, provides sensitivity and stability for advanced biophysical experiments.
• Versatile Intermediate: Useful for ligand design, enzyme mechanism studies, and preparing labeled peptides or proteins.
• Good Chemical Stability: Withstands standard lab conditions if protected from light, heat, and strong oxidizers.

Application Areas

• Sulfhydryl-selective spin labeling for EPR/EPR studies
• Protein structure, conformation, and dynamics investigations
• Labeled peptide/protein synthesis for binding and interaction studies
• Site-specific bioconjugation and click chemistry workflows
• Drug discovery, cell biology, environmental and material science uses

Safety & Handling

• Precautions: Use gloves, goggles, and lab coat. Avoid skin or eye contact, inhalation, and ingestion. Handle under subdued light.
• Storage: Store tightly sealed at 2–8°C, away from light, heat, and strong oxidizers or bases.
• Disposal: Dispose of according to local and national regulations for chemical waste.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert Manufacturing: Precise synthesis, high purity, and strict batch-to-batch consistency since 2013.
• Custom Synthesis: Flexible scale production for research and industry, fully adaptable to custom needs.
• Detailed Documentation: Certificate of Analysis (COA) and full QA supporting every batch.
• Collaborative Support: Responsive scientific and technical help for your advanced experimentation.

Request a Quote or Sample Today!
Accelerate your research and labeling projects with SRIRAMCHEM’s trusted 3-(2-Iodoacetamido)-Propyl. Contact us for pricing, samples, or custom synthesis inquiries to support your scientific goals.