2-Methyl-2-phenylpropanoic acid

Drive your antihistamine and NSAID analogue development with 2-methyl-2-phenylpropanoic acid (CAS No.: 826-55-1, CAT No.: SRCM-028). Also known as 2-phenylisobutyric acid, this ?,?-dimethylated arylacetic acid derivative serves as a key building block and intermediate in the synthesis of bilastine and related second-generation antihistamines, as well as chiral resolving agents and pharmaceutical process intermediates.

With a molecular formula of C₁₀H₁₂O₂ and a molecular weight of 164.20 g/mol, it appears as a white to light yellow crystalline powder with a melting point of 77?81°C. Sparingly soluble in water but readily soluble in organic solvents, its sterically hindered carboxylic acid supports selective esterification and amidation while maintaining stability in cross-coupling and resolution processes.

Product Highlights

Technical Features & Benefits

• • Bilastine Key Intermediate: Direct precursor in second-generation antihistamine synthesis via selective side-chain elaboration and cross-coupling.

• • Steric Hindrance Advantage: Gem-dimethyl substitution prevents ?-elimination and supports regioselective functionalization at the aromatic ring.

• • Chiral Resolving Agent: Forms diastereomeric salts with amines, enabling efficient resolution of racemic pharmaceutical intermediates.

• • High Crystalline Purity: Well-defined melting range (77?81?C) facilitates robust purification and QC in multi-kilogram campaigns.

• • Versatile Carboxylic Acid: Supports clean esterification, amidation, and salt formation for diverse analogue synthesis.

Application Areas

• • Pharmaceutical intermediate for bilastine and related non-sedating antihistamine APIs.

• • Building block for NSAID analogues and anti-inflammatory research compounds.

• • Chiral resolving agent for amine resolution in asymmetric synthesis workflows.

• • Reference standard for process impurity profiling and analytical method development.

• • Synthetic intermediate for quaternary ?-aryl carboxylic acids in medicinal chemistry SAR studies.

Safety & Handling

• • Causes skin and eye irritation; wear gloves, safety goggles, and lab coat during handling.

• • Avoid dust inhalation; handle powders in well-ventilated fume hood or area.

• • Store sealed in dry conditions at ambient temperature; incompatible with strong bases and oxidizers.

• • Dispose of as hazardous chemical waste according to local regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Proven expertise in antihistamine intermediates, chiral resolving agents, and pharmaceutical building blocks.

• • Custom synthesis scale-up from grams to multi-kilograms for bilastine and analogue programs.

• • Comprehensive analytical documentation: COA, NMR, HPLC, LC-MS for regulatory compliance.
• Technical support for resolution optimization, impurity control, and process technology transfer.

Request a Quote or Sample Today! Accelerate your bilastine development and antihistamine research with SRIRAMCHEM’s premium 2-methyl-2-phenylpropanoic acid. Contact the expert team for pricing, availability, or custom synthesis support.