1,2:5,6-Di-O-isopropylidene-D-mannitol

Elevate your carbohydrate chemistry, chiral synthesis, and organic research with 1,2:5,6-Di-O-isopropylidene-D-mannitol (CAS No.: 1707-77-3, CAT No.: SRCD-032). This diacetal-protected D-mannitol is a robust and selective synthetic intermediate renowned for use as a chiral auxiliary or resolving agent. The isopropylidene groups at the 1,2- and 5,6-positions protect the terminal diol functionalities, enabling precise regioselective derivatization and supporting the synthesis of optically active compounds, natural product analogues, and advanced glycomolecules.

With a molecular formula of C₁₀H₂₀O₆ and a molecular weight of 236.26 g/mol, this compound appears as a white to off-white crystalline solid. It dissolves well in a range of organic solvents such as dichloromethane, methanol, and acetone, accommodating a diverse spectrum of synthetic procedures.

Product Highlights

Technical Features & Benefits

• Diisopropylidene Protection: Effectively masks 1,2- and 5,6-diols for selective functionalization and enhanced chemical stability.
• Chiral Auxiliary: Essential for asymmetric synthesis, resolution of racemates, and the preparation of optically pure intermediates.
• Stable Bicyclic Acetal Structure: Maintains integrity under standard organic reaction conditions, supports downstream deprotection and modification steps.
• Excellent Solubility: Dissolves in a range of common solvents for ease of scale-up and process development.
• High Purity & Quality: Produced under stringent controls, suitable for sensitive research applications.

Application Areas

• Synthesis of chiral auxiliaries, glycomimetics, and oligosaccharides
• Asymmetric organic transformations and resolution of chiral molecules
• Synthesis of protected mannitol derivatives, polyols, and pharmaceuticals
• Template for regioselective modification in carbohydrate and natural product chemistry
• Academic and industrial carbohydrate R&D

Safety & Handling

• Use appropriate PPE: gloves, goggles, and lab coat
• Avoid inhalation, ingestion, and direct skin or eye contact
• Store tightly sealed, protected from light, heat, and moisture
• Dispose of all chemical waste in compliance with local, regional, and national regulations

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with robust analytical documentation: COA, NMR, HPLC, and LC-MS with every batch
• Advanced capability for custom synthesis from mg to multi-kg scale
• High-purity products and reliable supply chain since 2013
• Comprehensive customer and technical support tailored to your research needs

Request a Quote or Sample Today!
Accelerate your stereoselective syntheses and carbohydrate research with SRIRAMCHEM’s premium 1,2:5,6-Di-O-isopropylidene-D-mannitol. Contact our technical team now for pricing, availability, or custom synthesis solutions.